Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 7/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | MITF | O75030 | 1/20 | 0.51 |
| ▸ | AR | P10275 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8922348 | 1.00 | MAPT (0.58) | MAPTNPSR1MEN1KMT2ANPC1 | |
| SCHEMBL8922355 | 1.00 | MAPT (0.58) | MAPTNPSR1MEN1KMT2ANPC1 | |
| SCHEMBL7530877 | 0.81 | MAPT (0.62) | MAPTNPSR1MEN1KMT2ANPC1 | |
| SCHEMBL7530881 | 0.81 | MAPT (0.62) | MAPTNPSR1MEN1KMT2ANPC1 | |
| SCHEMBL8921387 | 0.79 | MAPT (0.50) | MAPTNPSR1NPC1RAB9AMAOB | |
| SCHEMBL8923719 | 0.79 | NFE2L2 (0.58) | MAPTNPSR1MEN1KMT2ANPC1 | |
| SCHEMBL8923713 | 0.79 | NFE2L2 (0.58) | MAPTNPSR1MEN1KMT2ANPC1 | |
| SCHEMBL8923723 | 0.79 | NFE2L2 (0.58) | MAPTNPSR1MEN1KMT2ANPC1 | |
| SCHEMBL8921396 | 0.79 | MAPT (0.50) | MAPTNPSR1NPC1RAB9AMAOB | |
| SCHEMBL8921393 | 0.79 | MAPT (0.50) | MAPTNPSR1NPC1RAB9AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0802897-A1 | NOVEL COMPOUNDS | Smithkline Beecham S.p.A. (IT) | 1997-10-29 | — | — | EP | disclosed |
| WO-1996021638-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM S.P.A. (IT) | 1996-07-18 | — | — | WO | disclosed |