Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 1/20 | 0.40 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.40 |
| ▸ | RAMP1 | O60894 | 3/20 | 0.39 |
| ▸ | CALCRL | Q16602 | 3/20 | 0.39 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.37 |
| ▸ | CCKBR | P32239 | 2/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8922260 | 0.85 | PLA2G10 (0.39) | PLA2G10PLA2G5RAMP1CALCRLSLC18A3 | |
| SCHEMBL8924459 | 0.84 | PLA2G10 (0.44) | PLA2G10PLA2G5RAMP1CALCRLCCKBR | |
| SCHEMBL8920820 | 0.80 | CCKBR (0.40) | PLA2G10PLA2G5RAMP1CALCRLCCKBR | |
| SCHEMBL8924367 | 0.80 | PLA2G10 (0.36) | PLA2G10PLA2G5RAMP1CALCRLRIPK1 | |
| SCHEMBL8920687 | 0.79 | CCKBR (0.38) | PLA2G10PLA2G5RAMP1CALCRLCCKBR | |
| SCHEMBL8920826 | 0.78 | CCKBR (0.61) | CCKBR | |
| SCHEMBL13929747 | 0.78 | RAMP1 (0.50) | PLA2G10PLA2G5RAMP1CALCRLRIPK1 | |
| SCHEMBL8921216 | 0.78 | RAMP1 (0.50) | PLA2G10PLA2G5RAMP1CALCRLRIPK1 | |
| SCHEMBL8920692 | 0.77 | CCKBR (0.57) | CCKBR | |
| SCHEMBL9515276 | 0.76 | PLA2G10 (0.36) | PLA2G10PLA2G5RAMP1CALCRL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5643904-A | Substituted hexahdryoazepinones and tetrahydrobenzazepinones | PFIZER INC. (US) | 1997-07-01 | — | — | US | disclosed |
| US-5484917-A | FOR TREATMENT AND PREVENTION OF GASTROINTESTINAL DISORDERS, PAIN AND ANXIETY | PFIZER INC. (US) | 1996-01-16 | — | — | US | disclosed |
| EP-0625145-A1 | 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS | PFIZER INC. (US) | 1994-11-23 | — | — | EP | disclosed |
| WO-1993015059-A1 | 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS | PFIZER INC. (US) | 1993-08-05 | — | — | WO | disclosed |