SCHEMBL8921473

SCHEMBL8921473

O=C1CCC(C2CCCCC2)c2ccccc21

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 1/20 0.46
MAPT P10636 3/20 0.45
HPGD P15428 1/20 0.45
CYP2A6 P11509 1/20 0.40
MAOA P21397 1/20 0.40
MAOB P27338 1/20 0.40
LMNA P02545 1/20 0.40
TSHR P16473 1/20 0.40
BCHE P06276 1/20 0.40
ACHE P22303 1/20 0.40
ALDH1A1 P00352 3/20 0.39
SIGMAR1 Q99720 2/20 0.39
PRCP P42785 1/20 0.39
HTR2A P28223 6/20 0.39
HTR2C P28335 6/20 0.39
HTR2B P41595 6/20 0.39
HRH3 Q9Y5N1 5/20 0.39
IDO1 P14902 1/20 0.38
TDO2 P48775 1/20 0.38
MEN1 O00255 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6587468 0.86 PARP1 (0.46) PARP1MAPTHPGDCYP2A6MAOA
SCHEMBL10407186 0.82 PARP1 (0.50) PARP1MAPTHPGDLMNATSHR
SCHEMBL18494344 0.79 PARP1 (0.46) PARP1MAPTMAOBLMNATSHR
SCHEMBL8400995 0.77 ALDH1A1 (0.51) PARP1MAPTHPGDMAOAMAOB
SCHEMBL8920864 0.77 HPGD (0.44) PARP1MAPTHPGDLMNABCHE
SCHEMBL8920861 0.77 HPGD (0.44) PARP1MAPTHPGDLMNABCHE
SCHEMBL21311830 0.76 CYP2A6 (0.35) PARP1MAPTHPGDCYP2A6MAOA
SCHEMBL11460515 0.76 SIGMAR1 (0.56) SIGMAR1PRCPHTR2AHTR2CHTR2B
SCHEMBL6643129 0.76 PARP1 (0.54) PARP1MAPTHPGDLMNATSHR
SCHEMBL5846237 0.76 PARP1 (0.54) PARP1MAPTHPGDLMNATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5643904-A Substituted hexahdryoazepinones and tetrahydrobenzazepinones PFIZER INC. (US) 1997-07-01 US disclosed
US-5484917-A FOR TREATMENT AND PREVENTION OF GASTROINTESTINAL DISORDERS, PAIN AND ANXIETY PFIZER INC. (US) 1996-01-16 US disclosed
EP-0625145-A1 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS PFIZER INC. (US) 1994-11-23 EP disclosed
WO-1993015059-A1 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS PFIZER INC. (US) 1993-08-05 WO disclosed