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Sugi Predict / Compounds / SCHEMBL8922381

SCHEMBL8922381

SCHEMBL8922381

CCOC(=O)COP(=O)(CN[C@@H](CCC(=O)O)Cc1ccc(-c2ccccc2)cc1)OCC(=O)OCC

nearest known ligand 0.63

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ MME P08473 5/20 0.49
▸ MMEL1 Q495T6 1/20 0.43
▸ ACE P12821 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8921950 0.90 MMEL1 (0.48) MMEMMEL1
SCHEMBL7413312 0.84 MME (0.45) MMEACE
SCHEMBL7343787 0.83 MMEL1 (0.51) MMEL1
SCHEMBL7411689 0.83 MME (0.57) MMEMMEL1ACE
SCHEMBL7414207 0.81 TACR1 (0.43) MMEL1ACE
SCHEMBL7407913 0.80 MME (0.56) MMEMMEL1ACE
SCHEMBL7412654 0.78 MME (0.62) MMEMMEL1ACE
SCHEMBL7412646 0.78 MME (0.62) MMEMMEL1ACE
SCHEMBL8922872 0.76 MME (0.46) MMEMMEL1
SCHEMBL8922845 0.76 MME (0.46) MMEMMEL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0660840-B1 PHOSPHONO SUBSTITUTED TETRAZOLE DERIVATIVES CIBA GEIGY AG (CH) 1997-05-07 — — EP disclosed
US-5550119-A ENDOTHELIN-CONVERTING ENZYM INHIBITORS CIBA-GEIGY CORPORATION (US) 1996-08-27 — — US disclosed
EP-0660840-A1 PHOSPHONO SUBSTITUTED TETRAZOLE DERIVATIVES. CIBA GEIGY AG (CH) 1995-07-05 — — EP disclosed
WO-1994005677-A1 PHOSPHONO SUBSTITUTED TETRAZOLE DERIVATIVES CIBA-GEIGY AG (CH) 1994-03-17 — — WO disclosed