Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.38 |
| ▸ | WNT3A | P56704 | 1/20 | 0.38 |
| ▸ | STING1 | Q86WV6 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6505055 | 0.87 | LMNA (0.44) | LMNACYP1A2CYP3A4MAOAMAPT | |
| SCHEMBL11738582 | 0.83 | STING1 (0.46) | LMNACYP1A2CYP3A4MAOAMAPT | |
| SCHEMBL5044662 | 0.80 | LMNA (0.59) | LMNACYP1A2CYP3A4MAOAMAPT | |
| SCHEMBL9254530 | 0.79 | LMNA (0.57) | LMNACYP1A2CYP3A4MAOAMAPT | |
| SCHEMBL6495442 | 0.79 | LMNA (0.54) | LMNAMAPTALDH1A1HPGDKMT2A | |
| SCHEMBL6650021 | 0.79 | LMNA (0.61) | LMNACYP1A2CYP3A4MAOAMAPT | |
| SCHEMBL7437710 | 0.78 | ATM (0.45) | CYP1A2CYP3A4MAPTALDH1A1HPGD | |
| SCHEMBL8125851 | 0.78 | LMNA (0.56) | LMNACYP1A2CYP3A4MAOAMAPT | |
| SCHEMBL4271044 | 0.77 | ALDH1A1 (0.51) | LMNAMAPTALDH1A1HPGDKMT2A | |
| SCHEMBL11703646 | 0.76 | CA12 (0.63) | MAPTALDH1A1HPGDKMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5684151-A | PROGESTIN AGONISTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1997-11-04 | — | — | US | disclosed |
| EP-0650480-A1 | 1-ARYLSULPHONYL, ARYLCARBONYL AND 1-ARYLPHOSPHONYL-3-PHENYL-1,4,5,6-TETRAHYDROPYRIDAZINES | ORTHO PHARMACEUTICAL CORPORATION (US) | 1995-05-03 | — | — | EP | disclosed |
| WO-1994001412-A1 | 1-ARYLSULPHONYL, ARYLCARBONYL AND 1-ARYLPHOSPHONYL-3-PHENYL-1,4,5,6-TETRAHYDROPYRIDAZINES | ORTHO PHARMACEUTICAL CORPORATION (US) | 1994-01-20 | — | — | WO | disclosed |