SCHEMBL8922566

SCHEMBL8922566

CC(C)(C)[Si](C)(C)OCC#CCc1cccnc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 4/20 0.38
CHRNA4 P43681 4/20 0.38
CYP1A2 P05177 2/20 0.37
CYP2C9 P11712 2/20 0.37
CYP2C19 P33261 2/20 0.37
CYP3A4 P08684 1/20 0.37
HIF1A Q16665 1/20 0.37
CYP2D6 P10635 1/20 0.37
L3MBTL1 Q9Y468 2/20 0.36
CHRNA7 P36544 2/20 0.36
TDP1 Q9NUW8 1/20 0.36
HTR1A P08908 1/20 0.36
DRD2 P14416 1/20 0.36
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
CYP2A6 P11509 2/20 0.35
CYP2B6 P20813 1/20 0.35
RIPK1 Q13546 1/20 0.35
NAPRT Q6XQN6 1/20 0.34
ALDH1A1 P00352 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5398670 0.82 CHRNB2 (0.44) CHRNB2CHRNA4CYP1A2CYP2D6L3MBTL1
SCHEMBL1246811 0.76 PRKCI (0.33)
SCHEMBL17036533 0.75 CHRNB2 (0.44) CHRNB2CHRNA4CYP1A2CYP2C9CYP2C19
SCHEMBL17036495 0.73 CHRNB2 (0.46) CHRNB2CHRNA4CYP1A2CYP2C9CYP2C19
SCHEMBL17039122 0.73 CHRNB2 (0.50) CHRNB2CHRNA4CYP1A2CYP2C9CYP2C19
SCHEMBL8662158 0.72 L3MBTL1 (0.55) L3MBTL1CHRNA7TDP1NPC1RAB9A
SCHEMBL8664580 0.72 HRH3 (0.35) CYP1A2TDP1HTR1ADRD2NPC1
SCHEMBL2168948 0.72
SCHEMBL742307 0.71 L3MBTL1 (0.54) L3MBTL1CHRNA7TDP1NPC1RAB9A
SCHEMBL743788 0.71 L3MBTL1 (0.54) L3MBTL1CHRNA7TDP1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5618821-A VIRICIDES, PICORNAVIRUS SANOFI, S.A. (FR) 1997-04-08 US disclosed
WO-1995031438-A1 THERAPEUTIC PHENOXYALKYLHETEROCYCLES SANOFI WINTHROP, INC. (US) 1995-11-23 WO disclosed