Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.32 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.32 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.32 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.30 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.30 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.30 |
| ▸ | IKBKB | O14920 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL501378 | 0.79 | MRGPRX4 (0.41) | PRKCICYP11B1CYP11B2ENPP2PDK1 | |
| SCHEMBL8922566 | 0.76 | CHRNB2 (0.38) | — | |
| SCHEMBL6522017 | 0.75 | FFAR1 (0.38) | PRKCIALK | |
| SCHEMBL21068770 | 0.74 | DUT (0.37) | PRKCICYP11B1CYP11B2ENPP2PDK1 | |
| SCHEMBL1247083 | 0.73 | CYP4F2 (0.37) | PRKCIS1PR1CYP11B1CYP11B2ENPP2 | |
| SCHEMBL4783563 | 0.72 | PRKCI (0.49) | PRKCIS1PR1KDR | |
| SCHEMBL21054993 | 0.72 | PRKCI (0.40) | PRKCIS1PR1CYP11B1CYP11B2ENPP2 | |
| SCHEMBL2168948 | 0.71 | — | — | |
| SCHEMBL16895309 | 0.70 | KDR (0.43) | KDR | |
| SCHEMBL559965 | 0.70 | KDR (0.41) | PRKCIENPP2PDK1PDK2PDK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459572-A2 | SPIROCYCLIC AMIDE DERIVATIVES | AstraZeneca AB (SE) | 2012-06-06 | — | — | EP | disclosed |
| WO-2011012896-A2 | COMPOUNDS - 801 | ASTRAZENECA AB (SE) | 2011-02-03 | — | — | WO | disclosed |