Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8918863 | 0.84 | MEN1 (0.39) | KDM4ELMNAPTPN11ALDH1A1MEN1 | |
| SCHEMBL28114866 | 0.77 | KDM4E (0.39) | CYP3A4KDM4ELMNAPTPN11ALDH1A1 | |
| SCHEMBL30204402 | 0.75 | BRPF1 (0.53) | KDM4ELMNAPTPN11MAPTALOX15 | |
| SCHEMBL19231292 | 0.73 | KDM4E (0.48) | CYP3A4KDM4ELMNAPTPN11ALDH1A1 | |
| SCHEMBL8919183 | 0.71 | CHEK1 (0.43) | CYP3A4KDM4ELMNAPTPN11ALDH1A1 | |
| SCHEMBL12419947 | 0.70 | HPGD (0.48) | KDM4ELMNAALDH1A1MEN1MAPT | |
| SCHEMBL11671459 | 0.69 | KDM4E (0.61) | KDM4ELMNAPTPN11ALDH1A1TDP1 | |
| SCHEMBL29136490 | 0.69 | CA1 (0.52) | KDM4ELMNAALDH1A1TDP1MAPT | |
| SCHEMBL6901103 | 0.68 | CA12 (0.50) | KDM4ELMNAALDH1A1TDP1MAPT | |
| SCHEMBL27279304 | 0.68 | CA1 (0.55) | KDM4ELMNAALDH1A1TDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5591751-A | CARBOSTYRIL DERIVATIVES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-01-07 | — | — | US | disclosed |
| EP-0636128-A1 | PIPERAZINOCARBONYLCARBOSTYRILS AS PERIPHERAL VASODILATORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-02-01 | — | — | EP | disclosed |
| WO-1994019339-A1 | PIPERAZINOCARBONYLCARBOSTYRILS AS PERIPHERAL VASODILATORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-09-01 | — | — | WO | disclosed |