Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | CSF1R | P07333 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | FRK | P42685 | 1/20 | 0.45 |
| ▸ | CLK2 | P49760 | 1/20 | 0.45 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.45 |
| ▸ | STK3 | Q13188 | 1/20 | 0.45 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8923307 | 0.78 | GPR17 (0.62) | KDM4ECSF1RCA1CA2ROCK2 | |
| SCHEMBL8923436 | 0.77 | KDM4E (0.52) | KDM4ECSF1RCA1CA2ROCK2 | |
| SCHEMBL8925470 | 0.77 | KDM4E (0.49) | KDM4ECSF1RCA1CA2ROCK2 | |
| SCHEMBL8923670 | 0.75 | KDM4E (0.55) | KDM4ECSF1RCA1CA2ROCK2 | |
| SCHEMBL8924079 | 0.74 | CSF1R (0.49) | KDM4ECSF1RCA1CA2ROCK2 | |
| SCHEMBL8925137 | 0.73 | ALDH1A1 (0.56) | KDM4ECSF1RCYP1A2POLBCYP3A4 | |
| SCHEMBL14268433 | 0.72 | CSF1R (0.60) | KDM4ECSF1RCA1CA2ROCK2 | |
| SCHEMBL8924235 | 0.72 | ALDH1A1 (0.57) | KDM4ECSF1RCYP1A2POLBCYP3A4 | |
| SCHEMBL8925697 | 0.70 | ALDH1A1 (0.58) | KDM4ECSF1RCYP1A2POLBCYP3A4 | |
| SCHEMBL8924042 | 0.70 | CA1 (0.66) | KDM4ECSF1RCA1CA2ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614532-A | NERVOUS SYSTEM DISORDERS USING N-METHYLASPARTATE ANTAGONIST | MERCK, SHARP & DOHME LTD. (GB) | 1997-03-25 | — | — | US | disclosed |