Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | ACP3 | P15309 | 1/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9420774 | 0.79 | SLC6A2 (0.41) | HSD17B2OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL3159928 | 0.78 | SLC6A4 (0.43) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL3687682 | 0.77 | IDO1 (0.44) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL151181 | 0.77 | IDO1 (0.44) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL1357184 | 0.76 | TP53 (0.37) | — | |
| SCHEMBL11834096 | 0.76 | IDO1 (0.44) | OPRM1OPRD1OPRK1OPRL1SLC6A4 | |
| Ethylene Glycol SCHEMBL8153345 | 0.74 | CHRM2 (0.38) | — | |
| SCHEMBL9630636 | 0.73 | GBA1 (0.36) | — | |
| SCHEMBL11840463 | 0.72 | TP53 (0.42) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL2271173 | 0.72 | SLC6A3 (0.48) | SLC6A4SLC6A2SLC6A3AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1254465-C | Calcilytic compounds | NPS PHARMA INC (US) | 2006-05-03 | — | — | CN | disclosed |
| CN-1221401-A | Calcilytic compounds | NPS PHARMA INC (US) | 1999-06-30 | — | — | CN | disclosed |
| US-5614518-A | Morpholine derivatives as dopamine receptor subtype ligands | MERCK SHARP & DOHME LTD. (GB) | 1997-03-25 | — | — | US | disclosed |
| EP-0730593-A1 | MORPHOLINE DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LTD. (GB) | 1996-09-11 | — | — | EP | disclosed |
| WO-1995014690-A1 | MORPHOLINE DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 1995-06-01 | — | — | WO | disclosed |