SCHEMBL8924672

SCHEMBL8924672

CC(=O)Oc1cccc2c1c(CC(N)=O)cn2Cc1ccccc1

nearest known ligand 0.72

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PLA2G2A P14555 13/20 0.72
ICMT O60725 7/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7961599 0.88 PLA2G2A (0.76) PLA2G2AICMT
SCHEMBL7966181 0.84 PLA2G2A (1.00) PLA2G2AICMT
SCHEMBL7962192 0.83 PLA2G2A (0.80) PLA2G2AICMT
SCHEMBL7963378 0.81 PLA2G2A (0.67) PLA2G2AICMT
SCHEMBL6775064 0.79 PLA2G2A (0.65) PLA2G2AICMT
SCHEMBL4668109 0.78 PLA2G2A (0.46) PLA2G2A
SCHEMBL8924591 0.78 PLA2G2A (0.61) PLA2G2AICMT
SCHEMBL8924667 0.78 PLA2G2A (0.64) PLA2G2AICMT
SCHEMBL8924447 0.76 PLA2G2A (0.80) PLA2G2A
SCHEMBL8924596 0.76 PLA2G2A (0.59) PLA2G2AICMT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5684034-A INHIBITORS OF HUMAN NON-PANCREATIC SECRETORY PHOSPHOLIPASE A2, TREATMENT OF SEPTIC SHOCK, TRAUMA, RESPIRATORY DISORDERS, RHEUMATIC ARTHRITIS, INHIBITORS OF ARACHIDONIC ACID RELEASE ELI LILLY AND COMPANY (US) 1997-11-04 US disclosed