Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 9/20 | 0.67 |
| ▸ | ICMT | O60725 | 8/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2005309 | 0.89 | ALDH1A1 (0.58) | PLA2G2AALDH1A1LMNAP2RX7 | |
| SCHEMBL27362634 | 0.87 | PLA2G2A (0.53) | PLA2G2AICMT | |
| SCHEMBL8924667 | 0.84 | PLA2G2A (0.64) | PLA2G2AICMTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7961599 | 0.83 | PLA2G2A (0.76) | PLA2G2AICMT | |
| SCHEMBL2007475 | 0.82 | ALDH1A1 (0.50) | PLA2G2AALDH1A1LMNA | |
| SCHEMBL7966181 | 0.81 | PLA2G2A (1.00) | PLA2G2AICMT | |
| SCHEMBL8924672 | 0.81 | PLA2G2A (0.72) | PLA2G2AICMT | |
| SCHEMBL8289938 | 0.81 | PLA2G2A (0.74) | PLA2G2AICMTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL2003482 | 0.80 | ALDH1A1 (0.54) | PLA2G2AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL8924591 | 0.79 | PLA2G2A (0.61) | PLA2G2AICMTP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6252084-B1 | THERAPY FOR SEPSIS SHOCK | ELI LILLY AND COMPANY | 2001-06-26 | — | — | US | disclosed |
| EP-0620215-B1 | 1H-indole-3-acetamide derivatives as sPLA2 inhibitors | LILLY CO ELI (US) | 1999-08-18 | — | — | EP | disclosed |
| US-5684034-A | INHIBITORS OF HUMAN NON-PANCREATIC SECRETORY PHOSPHOLIPASE A2, TREATMENT OF SEPTIC SHOCK, TRAUMA, RESPIRATORY DISORDERS, RHEUMATIC ARTHRITIS, INHIBITORS OF ARACHIDONIC ACID RELEASE | ELI LILLY AND COMPANY (US) | 1997-11-04 | — | — | US | disclosed |
| EP-0620215-A1 | 1H-indole-3-acetamide derivatives as sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 1994-10-19 | — | — | EP | disclosed |