Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 9/20 | 0.61 |
| ▸ | ICMT | O60725 | 7/20 | 0.49 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8924667 | 0.88 | PLA2G2A (0.64) | PLA2G2AICMTADORA1 | |
| SCHEMBL7961599 | 0.82 | PLA2G2A (0.76) | PLA2G2AICMT | |
| SCHEMBL7963378 | 0.79 | PLA2G2A (0.67) | PLA2G2AICMTP2RX7 | |
| SCHEMBL8924596 | 0.79 | PLA2G2A (0.59) | PLA2G2AICMTP2RX7 | |
| SCHEMBL7962192 | 0.79 | PLA2G2A (0.80) | PLA2G2AICMT | |
| SCHEMBL8924672 | 0.78 | PLA2G2A (0.72) | PLA2G2AICMT | |
| SCHEMBL8926033 | 0.77 | PLA2G2A (0.70) | PLA2G2A | |
| SCHEMBL8926207 | 0.76 | PLA2G2A (0.71) | PLA2G2A | |
| SCHEMBL7966181 | 0.76 | PLA2G2A (1.00) | PLA2G2AICMT | |
| SCHEMBL703149 | 0.73 | PLA2G2A (0.44) | PLA2G2AP2RX7HDAC10HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5684034-A | INHIBITORS OF HUMAN NON-PANCREATIC SECRETORY PHOSPHOLIPASE A2, TREATMENT OF SEPTIC SHOCK, TRAUMA, RESPIRATORY DISORDERS, RHEUMATIC ARTHRITIS, INHIBITORS OF ARACHIDONIC ACID RELEASE | ELI LILLY AND COMPANY (US) | 1997-11-04 | — | — | US | disclosed |