SCHEMBL8924727

SCHEMBL8924727

CCCP(=O)(O)OOc1cc2c(CC(N)=O)cn(Cc3ccccc3)c2cc1Cl

nearest known ligand 0.56

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PLA2G2A P14555 10/20 0.56
ICMT O60725 10/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8926990 0.85 PLA2G2A (0.70) PLA2G2AICMT
SCHEMBL8924722 0.78 PLA2G2A (0.53) PLA2G2AICMT
SCHEMBL8924312 0.74 PLA2G2A (0.72) PLA2G2AICMT
SCHEMBL7961585 0.74 PLA2G2A (0.81) PLA2G2AICMT
SCHEMBL8926059 0.74 PLA2G2A (0.71) PLA2G2AICMT
SCHEMBL7952366 0.72 PLA2G2A (1.00) PLA2G2AICMT
SCHEMBL8924715 0.72 PLA2G2A (0.53) PLA2G2AICMT
SCHEMBL8926140 0.71 PLA2G2A (0.53) PLA2G2AICMT
SCHEMBL8924302 0.70 PLA2G2A (0.68) PLA2G2AICMT
SCHEMBL8924693 0.70 PLA2G2A (0.70) PLA2G2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5684034-A INHIBITORS OF HUMAN NON-PANCREATIC SECRETORY PHOSPHOLIPASE A2, TREATMENT OF SEPTIC SHOCK, TRAUMA, RESPIRATORY DISORDERS, RHEUMATIC ARTHRITIS, INHIBITORS OF ARACHIDONIC ACID RELEASE ELI LILLY AND COMPANY (US) 1997-11-04 US disclosed