SCHEMBL8924722

SCHEMBL8924722

CCCO[PH](=O)Oc1cc2c(CC(N)=O)cn(Cc3ccccc3)c2cc1Cl

nearest known ligand 0.53

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PLA2G2A P14555 9/20 0.53
ICMT O60725 11/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8926987 0.85 PLA2G2A (0.68) PLA2G2AICMT
SCHEMBL8924727 0.78 PLA2G2A (0.56) PLA2G2AICMT
SCHEMBL8924309 0.73 PLA2G2A (0.77) PLA2G2AICMT
SCHEMBL7963252 0.70 PLA2G2A (1.00) PLA2G2AICMT
SCHEMBL8289938 0.69 PLA2G2A (0.74) PLA2G2AICMT
SCHEMBL7965309 0.69 PLA2G2A (1.00) PLA2G2AICMT
SCHEMBL8924688 0.69 PLA2G2A (0.69) PLA2G2A
SCHEMBL8926742 0.69 PLA2G2A (0.48) PLA2G2AICMT
SCHEMBL7953321 0.68 PLA2G2A (1.00) PLA2G2AICMT
SCHEMBL8927004 0.68 PLA2G2A (0.72) PLA2G2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5684034-A INHIBITORS OF HUMAN NON-PANCREATIC SECRETORY PHOSPHOLIPASE A2, TREATMENT OF SEPTIC SHOCK, TRAUMA, RESPIRATORY DISORDERS, RHEUMATIC ARTHRITIS, INHIBITORS OF ARACHIDONIC ACID RELEASE ELI LILLY AND COMPANY (US) 1997-11-04 US disclosed