Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 4/20 | 0.41 |
| ▸ | FAAH | O00519 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.39 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8921612 | 0.82 | SMN1; SMN2 (0.37) | SMN1; SMN2CES1FAAHKDM4EALDH1A1 | |
| SCHEMBL8922395 | 0.80 | CYP4A11 (0.47) | SMN1; SMN2ALOX15HPGDALDH1A1LMNA | |
| SCHEMBL8924828 | 0.80 | SMN1; SMN2 (0.43) | SMN1; SMN2KDM4EHSP90AA1ALOX15MAPK1 | |
| SCHEMBL8921268 | 0.80 | CYP4F2 (0.52) | FAAHHPGDALDH1A1 | |
| SCHEMBL8783999 | 0.79 | POLB (0.55) | SMN1; SMN2KDM4EMAPK1HPGDPOLB | |
| SCHEMBL8920119 | 0.78 | SMN1; SMN2 (0.51) | SMN1; SMN2KDM4EALOX15MAPK1HPGD | |
| SCHEMBL8921856 | 0.76 | POLB (0.41) | KDM4EHSP90AA1MAPK1POLBALDH1A1 | |
| SCHEMBL8921377 | 0.74 | ALDH1A1 (0.46) | KDM4EHPGDALDH1A1LMNA | |
| SCHEMBL8921279 | 0.70 | MEN1 (0.40) | SMN1; SMN2KDM4EHPGDPOLBALDH1A1 | |
| SCHEMBL8921195 | 0.68 | MAPT (0.48) | SMN1; SMN2HPGDALDH1A1HSP90B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5633379-A | N-METHYLASPARTIC ACID ANTAGONIST | CIBA-GEIGY CORPORATION (US) | 1997-05-27 | — | — | US | disclosed |
| EP-0685466-A1 | 3-Heteroaliphatyle-and 3-hetero-(aryle)-aliphatyle-2(1H)-quinolone derivatives | CIBA-GEIGY AG (CH) | 1995-12-06 | — | — | EP | disclosed |