Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8920266 | 0.81 | GAA (0.54) | SMN1; SMN2KDM4EMAPTALDH1A1LMNA | |
| SCHEMBL8922901 | 0.79 | MAPT (0.57) | SMN1; SMN2PLA2G2AKDM4EMAPTALDH1A1 | |
| SCHEMBL8921187 | 0.78 | MEN1 (0.56) | SMN1; SMN2PLA2G2AKDM4EMAPTALDH1A1 | |
| SCHEMBL8924835 | 0.78 | SMN1; SMN2 (0.43) | SMN1; SMN2KDM4EALDH1A1LMNAALOX15 | |
| SCHEMBL8920117 | 0.77 | MAPT (0.60) | SMN1; SMN2PLA2G2AKDM4EMAPTALDH1A1 | |
| SCHEMBL10362701 | 0.76 | ALDH1A1 (0.72) | KDM4EMAPTALDH1A1LMNAMEN1 | |
| SCHEMBL8922431 | 0.75 | KDM4E (0.78) | SMN1; SMN2KDM4EMAPTALDH1A1LMNA | |
| SCHEMBL8920196 | 0.74 | MAPT (0.74) | KDM4EMAPTALDH1A1LMNAMEN1 | |
| SCHEMBL8921144 | 0.72 | MAPT (0.48) | SMN1; SMN2PLA2G2AKDM4EMAPTALDH1A1 | |
| SCHEMBL8921612 | 0.72 | SMN1; SMN2 (0.37) | SMN1; SMN2KDM4EALDH1A1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5633379-A | N-METHYLASPARTIC ACID ANTAGONIST | CIBA-GEIGY CORPORATION (US) | 1997-05-27 | — | — | US | disclosed |
| EP-0685466-A1 | 3-Heteroaliphatyle-and 3-hetero-(aryle)-aliphatyle-2(1H)-quinolone derivatives | CIBA-GEIGY AG (CH) | 1995-12-06 | — | — | EP | disclosed |