Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.75 |
| ▸ | LMNA | P02545 | 3/20 | 0.69 |
| ▸ | HPGD | P15428 | 2/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.69 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.69 |
| ▸ | TOP2A | P11388 | 1/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.68 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.64 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.64 |
| ▸ | PIK3R1 | P27986 | 5/20 | 0.64 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.64 |
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8192604 | 0.90 | KDM4E (0.78) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL8924080 | 0.89 | KDM4E (0.80) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL10807306 | 0.88 | KDM4E (0.81) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL4717846 | 0.86 | KDM4E (0.69) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL29350842 | 0.86 | KDM4E (1.00) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL10809240 | 0.86 | KDM4E (1.00) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL5570774 | 0.86 | KDM4E (0.77) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL8924402 | 0.86 | ALDH1A1 (0.77) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL10815692 | 0.85 | KDM4E (0.80) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL15506932 | 0.85 | KDM4E (0.77) | KDM4EALDH1A1LMNAHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5631256-A | IMPROVED POTENCY, BROADER SPECTRUM | THE PROCTER & GAMBLE COMPANY (US) | 1997-05-20 | — | — | US | disclosed |
| US-5328908-A | Antimicrobial quinolone thioureas | PROCTER & GAMBLE PHARMACEUTICALS, INC. (US) | 1994-07-12 | — | — | US | disclosed |
| EP-0593457-A1 | ANTIMICROBIAL QUINOLONE THIOUREAS | Norwich-Eaton Pharmaceuticals, Inc. (US) | 1994-04-27 | — | — | EP | disclosed |
| EP-0593457-A4 | ANTIMICROBIAL QUINOLONE THIOUREAS. | NORWICH EATON PHARMA (US) | 1993-01-15 | — | — | EP | disclosed |
| WO-1991016310-A1 | ANTIMICROBIAL QUINOLONE THIOUREAS | NORWICH-EATON PHARMACEUTICALS, INC. (US) | 1991-10-31 | — | — | WO | disclosed |