SCHEMBL8924902

SCHEMBL8924902

C=C(c1ccccc1N(C)C)c1ccccc1N(C)C

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.61
GAA P10253 3/20 0.61
TSHR P16473 2/20 0.61
ALDH1A1 P00352 2/20 0.61
SMN1; SMN2 Q16637 2/20 0.61
TP53 P04637 1/20 0.61
CNR2 P34972 2/20 0.42
KMT2A Q03164 2/20 0.42
MEN1 O00255 1/20 0.42
KDM4E B2RXH2 1/20 0.39
CHEK1 O14757 1/20 0.39
NEK2 P51955 1/20 0.39
LIMK1 P53667 1/20 0.39
DYRK1A Q13627 1/20 0.39
CLK4 Q9HAZ1 1/20 0.39
EP300 Q09472 1/20 0.38
KAT2B Q92831 1/20 0.38
KAT8 Q9H7Z6 1/20 0.38
PTPN1 P18031 2/20 0.35
LMNA P02545 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29365484 1.00 MAPT (0.61) MAPTGAATSHRALDH1A1SMN1; SMN2
SCHEMBL9126623 0.87 MEN1 (0.55) MAPTGAATSHRALDH1A1SMN1; SMN2
SCHEMBL8578207 0.84 GAA (0.59) MAPTGAATSHRALDH1A1SMN1; SMN2
SCHEMBL23940172 0.83 MAPT (0.53) MAPTGAATSHRALDH1A1SMN1; SMN2
SCHEMBL2267690 0.82 MAPT (0.57) MAPTGAATSHRALDH1A1SMN1; SMN2
SCHEMBL19685318 0.80 MAPT (0.55) MAPTGAATSHRALDH1A1SMN1; SMN2
SCHEMBL2491643 0.80 MAPT (0.67) MAPTGAATSHRALDH1A1SMN1; SMN2
SCHEMBL24050331 0.79 GAA (0.53) MAPTGAATSHRALDH1A1SMN1; SMN2
SCHEMBL18281547 0.77 MAPT (0.69) MAPTGAATSHRALDH1A1SMN1; SMN2
SCHEMBL22478577 0.77 TSHR (0.56) MAPTGAATSHRALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5676884-A Nonlinear optical materials containing polar disulfone-functionalized molecules MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1997-10-14 US disclosed
US-5578251-A NONLINEAR-OPTICAL RESPONSE; ALKYLATION MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1996-11-26 US disclosed
US-5360582-A Compositions with polymers for light sensitive elements MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1994-11-01 US disclosed
EP-0594697-A1 NONLINEAR OPTICAL MATERIALS CONTAINING POLAR DISULFONE-FUNCTIONALIZED MOLECULES MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1994-05-04 EP disclosed
WO-1993002383-A1 NONLINEAR OPTICAL MATERIALS CONTAINING POLAR DISULFONE-FUNCTIONALIZED MOLECULES MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1993-02-04 WO disclosed