Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 8/20 | 0.64 |
| ▸ | RHOC | P08134 | 1/20 | 0.55 |
| ▸ | RHOA | P61586 | 1/20 | 0.55 |
| ▸ | DAGLA | Q9Y4D2 | 7/20 | 0.51 |
| ▸ | ABHD6 | Q9BV23 | 5/20 | 0.51 |
| ▸ | TACR3 | P29371 | 1/20 | 0.49 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22901699 | 0.94 | TACR1 (0.71) | TACR1RHOCRHOADAGLAABHD6 | |
| SCHEMBL8923556 | 0.84 | TACR1 (0.58) | TACR1DAGLAABHD6TACR3SCD5 | |
| SCHEMBL4438135 | 0.83 | RHOC (0.73) | TACR1RHOCRHOA | |
| SCHEMBL9113036 | 0.79 | TACR1 (0.78) | TACR1RHOCRHOATACR3 | |
| SCHEMBL9112230 | 0.79 | TACR1 (0.78) | TACR1RHOCRHOATACR3 | |
| SCHEMBL7459083 | 0.78 | TACR1 (1.00) | TACR1RHOCRHOATACR3 | |
| SCHEMBL13818185 | 0.78 | TACR1 (0.77) | TACR1RHOCRHOATACR3 | |
| SCHEMBL8297226 | 0.78 | TACR1 (1.00) | TACR1RHOCRHOATACR3 | |
| SCHEMBL1534317 | 0.78 | RHOC (0.65) | TACR1RHOCRHOA | |
| SCHEMBL7643493 | 0.77 | TACR1 (0.81) | TACR1TACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5646144-A | FOR TREATING DISORDERS IN WHICH SUBSTANCE P PLAYS A PART IN DEVELOPMENT | CIBA-GEIGY CORPORATION (US) | 1997-07-08 | — | — | US | disclosed |
| US-5541195-A | SUBSTANCE P ANTAGONISTS | CIBA-GEIGY CORPORATION (US) | 1996-07-30 | — | — | US | disclosed |
| US-5310743-A | Substance P antagonist | CIBA-GEIGY CORP. (US) | 1994-05-10 | — | — | US | disclosed |