Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 6/20 | 0.58 |
| ▸ | TACR3 | P29371 | 1/20 | 0.48 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.47 |
| ▸ | DAGLA | Q9Y4D2 | 6/20 | 0.46 |
| ▸ | ABHD6 | Q9BV23 | 4/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | DAGLB | Q8NCG7 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8925154 | 0.84 | TACR1 (0.64) | TACR1TACR3SCD5DAGLAABHD6 | |
| SCHEMBL8926045 | 0.76 | TACR1 (0.71) | TACR1TACR3 | |
| SCHEMBL8499799 | 0.76 | TACR1 (0.71) | TACR1TACR3 | |
| SCHEMBL8925841 | 0.76 | TACR1 (0.71) | TACR1TACR3 | |
| SCHEMBL22901699 | 0.76 | TACR1 (0.71) | TACR1TACR3SCD5DAGLAABHD6 | |
| SCHEMBL8924617 | 0.75 | DAGLA (0.51) | DAGLAABHD6HSD11B1DAGLB | |
| SCHEMBL21138521 | 0.74 | HSD11B1 (0.62) | SCD5DAGLAABHD6HSD11B1DAGLB | |
| SCHEMBL4964339 | 0.74 | HSD11B1 (0.61) | SCD5DAGLAABHD6HSD11B1DAGLB | |
| SCHEMBL4629395 | 0.74 | HSD11B1 (0.61) | SCD5DAGLAABHD6HSD11B1DAGLB | |
| SCHEMBL8821463 | 0.73 | TACR1 (1.00) | TACR1TACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5646144-A | FOR TREATING DISORDERS IN WHICH SUBSTANCE P PLAYS A PART IN DEVELOPMENT | CIBA-GEIGY CORPORATION (US) | 1997-07-08 | — | — | US | disclosed |
| US-5541195-A | SUBSTANCE P ANTAGONISTS | CIBA-GEIGY CORPORATION (US) | 1996-07-30 | — | — | US | disclosed |
| US-5310743-A | Substance P antagonist | CIBA-GEIGY CORP. (US) | 1994-05-10 | — | — | US | disclosed |