Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 8/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 8/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TYR | P14679 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | ESRRG | P62508 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1181137 | 0.82 | ENPP2 (0.41) | ENPP2ESR1ESR2CYP3A4LMNA | |
| SCHEMBL26452 | 0.80 | TRPV6 (0.44) | ENPP2ESR1ESR2CYP3A4HSD17B10 | |
| SCHEMBL6609673 | 0.77 | ESR1 (0.38) | ENPP2ESR1ESR2CYP3A4LMNA | |
| SCHEMBL1507183 | 0.75 | TRPV6 (0.39) | ENPP2HSD17B10TSHRALDH1A1CA1 | |
| SCHEMBL29267529 | 0.75 | ENPP2 (0.58) | ENPP2 | |
| SCHEMBL1290227 | 0.75 | ENPP2 (0.52) | ENPP2ESR1ESR2CYP3A4LMNA | |
| SCHEMBL31416487 | 0.74 | ENPP2 (0.41) | ENPP2ESR1ESR2CYP3A4LMNA | |
| SCHEMBL27996709 | 0.70 | ENPP2 (0.52) | ENPP2ESR1ESR2CYP3A4LMNA | |
| SCHEMBL22536178 | 0.70 | ENPP2 (0.46) | ENPP2ESR1ESR2CYP3A4LMNA | |
| SCHEMBL17476000 | 0.68 | ENPP2 (0.71) | ENPP2ESR1ESR2CYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5622962-A | PROSTATE CANCER, SKIN DISORDERS, BALDNESS | ELI LILLY AND COMPANY (US) | 1997-04-22 | — | — | US | disclosed |
| US-5578724-A | INHIBITORS OF 5-ALPHA-REDUCTASE | ELI LILLY AND COMPANY (US) | 1996-11-26 | — | — | US | disclosed |
| WO-1996035422-A1 | METHODS FOR INHIBITING BONE LOSS | ELI LILLY AND COMPANY (US) | 1996-11-14 | — | — | WO | disclosed |