Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 8/20 | 0.45 |
| ▸ | PPARG | P37231 | 5/20 | 0.45 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8924425 | 0.92 | PPARA (0.44) | PPARAPPARGSOAT1TSHRHDAC1 | |
| SCHEMBL8768938 | 0.92 | PPARA (0.54) | PPARAPPARGSOAT1TSHRHDAC1 | |
| SCHEMBL8768980 | 0.90 | PPARA (0.50) | PPARAPPARGSOAT1TSHRHDAC1 | |
| SCHEMBL8925832 | 0.85 | PPARA (0.43) | PPARAPPARGSOAT1TSHRHDAC1 | |
| SCHEMBL8925468 | 0.84 | PPARA (0.47) | PPARAPPARGSOAT1TSHRHDAC1 | |
| SCHEMBL8768759 | 0.83 | PPARA (0.53) | PPARAPPARGSOAT1HDAC1HDAC6 | |
| SCHEMBL8768099 | 0.83 | TSHR (0.52) | PPARAPPARGTSHRHDAC1HDAC6 | |
| SCHEMBL8768838 | 0.83 | PPARA (0.48) | PPARAPPARGSOAT1TSHRHDAC1 | |
| SCHEMBL8925577 | 0.83 | PPARA (0.60) | PPARAPPARGTSHRGAAHTT | |
| SCHEMBL8767877 | 0.82 | HDAC6 (0.59) | PPARAPPARGSOAT1TSHRHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5658944-A | ANTICHOLESTEROL AGENTS | THE UNIVERSITY OF SOUTH CAROLINA (US) | 1997-08-19 | — | — | US | disclosed |
| EP-0639178-A1 | ANTI-ATHEROSCLEROTIC ARYL COMPOUNDS. | WELLCOME FOUND (GB) | 1995-02-22 | — | — | EP | disclosed |
| WO-1992010468-A1 | ANTI-ATHEROSCLEROTIC ARYL COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-06-25 | — | — | WO | disclosed |