Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BID | P55957 | 1/20 | 0.44 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.41 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.39 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8925786 | 0.88 | BID (0.47) | BIDBCL2L1MCL1BAK1MAPT | |
| Lithium SCHEMBL8925472 | 0.86 | BID (0.46) | BIDBCL2L1MCL1BAK1MAPT | |
| SCHEMBL8925461 | 0.86 | BID (0.46) | BIDBCL2L1MCL1BAK1MAPT | |
| SCHEMBL11205171 | 0.72 | HDAC1 (0.49) | MAPTRXFP1HDAC1HDAC2HDAC3 | |
| SCHEMBL11209645 | 0.72 | MAPT (0.46) | MAPTRXFP1HDAC1HDAC2HDAC3 | |
| SCHEMBL9560079 | 0.72 | ALDH1A1 (0.40) | MAPK1 | |
| SCHEMBL15194585 | 0.69 | THRA (0.41) | BIDBCL2L1MCL1BAK1CYSLTR2 | |
| SCHEMBL11203965 | 0.69 | HDAC1 (0.51) | MAPTRXFP1HDAC1HDAC2HDAC3 | |
| SCHEMBL11203828 | 0.67 | MAPT (0.50) | MAPTRXFP1HDAC1HDAC2HDAC3 | |
| Lithium Ion SCHEMBL9188017 | 0.67 | BID (0.48) | BIDBCL2L1MCL1BAK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5693857-A | Process and intermediate for the preparation of 2-hydroxy-3-sulfido-3-phenyl propanoic acids | SMITHKLINE BEECHAM CORPORATION (US) | 1997-12-02 | — | — | US | disclosed |