SCHEMBL8925930

SCHEMBL8925930

COC(=O)C(Cl)C(Cl)c1ccccc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.60
MEN1 O00255 2/20 0.45
PTGS1 P23219 1/20 0.45
PTGS2 P35354 1/20 0.45
ALDH1A1 P00352 1/20 0.45
LMNA P02545 1/20 0.45
HDAC3 O15379 1/20 0.42
HDAC4 P56524 1/20 0.42
HDAC1 Q13547 1/20 0.42
HDAC7 Q8WUI4 1/20 0.42
HDAC2 Q92769 1/20 0.42
HDAC10 Q969S8 1/20 0.42
HDAC11 Q96DB2 1/20 0.42
HDAC8 Q9BY41 1/20 0.42
HDAC6 Q9UBN7 1/20 0.42
HDAC9 Q9UKV0 1/20 0.42
HDAC5 Q9UQL6 1/20 0.42
TSHR P16473 1/20 0.42
CTSD P07339 1/20 0.41
SLC6A3 Q01959 4/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10797695 0.85 LMNA (0.45) KMT2AMEN1PTGS1PTGS2ALDH1A1
SCHEMBL31556283 0.83 KMT2A (0.58) KMT2AMEN1PTGS1PTGS2ALDH1A1
SCHEMBL9543022 0.83 KMT2A (0.58) KMT2AMEN1PTGS1PTGS2ALDH1A1
SCHEMBL6945334 0.81 KMT2A (0.56) KMT2AMEN1PTGS1PTGS2ALDH1A1
SCHEMBL6945331 0.81 KMT2A (0.56) KMT2AMEN1PTGS1PTGS2ALDH1A1
SCHEMBL10979168 0.81 KMT2A (0.56) KMT2AMEN1PTGS1PTGS2ALDH1A1
SCHEMBL8926506 0.81 MMP8 (0.53) KMT2AMEN1TSHRSLC6A3SLC6A2
SCHEMBL10797697 0.81 KMT2A (0.44) KMT2APTGS1PTGS2ALDH1A1LMNA
SCHEMBL1526022 0.80 KMT2A (0.64) KMT2AMEN1PTGS1PTGS2ALDH1A1
SCHEMBL10480681 0.78 KMT2A (0.51) KMT2AMEN1PTGS1PTGS2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5663365-A Process for the preparation of pyrazolones JAPAN HYDRAZINE CO., LTD. (JP) 1997-09-02 US disclosed
EP-0192111-B1 ISO-UREAS, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS HERBICIDES BASF Aktiengesellschaft (DE) 1990-05-16 EP disclosed
EP-0121129-B1 2,5-DIHYDRO-5-ARYLIMINO-PYRROLES, PROCESS FOR THEIR PRODUCTION AND THEIR USES AS HERBICIDES BASF Aktiengesellschaft (DE) 1989-02-01 EP disclosed
US-4789747-A BROAD LEAF PLANTS, GRASSES, WEEDS BASF AKTIENGESELLSCHAFT (DE) 1988-12-06 US disclosed
US-4761175-A M-anilido-urethanes and herbicides containing these compounds BASF AKTIENGESELLSCHAFT (DE) 1988-08-02 US disclosed
US-4744812-A HALOGENATED DIPHENYL ETHER BASF AKTIENGESELLSCHAFT (DE) 1988-05-17 US disclosed
US-4726837-A Use of 4H-pyrido[2,3-d][1,3]oxazin-4-one derivatives for controlling undesirable plant growth BASF AKTIENGESELLSCHAFT (DE) 1988-02-23 US disclosed
US-4715889-A HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 1987-12-29 US disclosed
US-4632696-A POSTEMERGENCE, PREEMERGENCE APPLICATIONS BASF AKTIENGESELLSCHAFT (DE) 1986-12-30 US disclosed
EP-0192111-A1 Iso-ureas, processes for their production and their use as herbicides BASF Aktiengesellschaft (DE) 1986-08-27 EP disclosed
EP-0019760-B1 ESTERS OF 3-ARYL-5-METHYL-PYRAZOLE-4-CARBOXYLIC ACID, HERBICIDES CONTAINING THEM, PROCESS FOR THEIR PREPARATION AND THEIR USE BASF Aktiengesellschaft (DE) 1982-06-23 EP disclosed
EP-0053679-A1 Diphenyl ether, preparation and use as herbicide BASF Aktiengesellschaft (DE) 1982-06-16 EP disclosed
EP-0053698-A1 5-Amino-1-phenylpyrazole-4-carboxylic acids, process for their preparation, herbicides containing them and their use as herbicides BASF Aktiengesellschaft (DE) 1982-06-16 EP disclosed
EP-0051155-A1 Use of 2-aryloxy-2-azolylalkanecarbonic amides as herbicides and herbicides containing these amides BASF Aktiengesellschaft (DE) 1982-05-12 EP disclosed
EP-0024570-B1 5-IMINO-IMIDAZOLINE-2-ONES, HERBICIDES CONTAINING THEM AND PROCESS FOR DESTRUCTING UNDESIRED PLANTS BASF Aktiengesellschaft (DE) 1982-05-12 EP disclosed
US-4321371-A Substituted N-benzoylanthranilic acid derivatives and their anhydro compounds BASF AKTIENGESELLSCHAFT (DE) 1982-03-23 US disclosed
US-4316014-A HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 1982-02-16 US disclosed
EP-0037925-A1 Substituted pyridazinones, process for their preparation, herbicides containing them and their use as herbicides BASF Aktiengesellschaft (DE) 1981-10-21 EP disclosed
EP-0032242-A1 4H-3,1-benzoxazine derivatives, process for their preparation and their use in inhibiting the growth of unwanted plants BASF Aktiengesellschaft (DE) 1981-07-22 EP disclosed
EP-0028355-A1 1,2-Oxazolylalkyl carbamates, their preparation, their use as herbicides, and herbicides BASF Aktiengesellschaft (DE) 1981-05-13 EP disclosed