SCHEMBL8926076

SCHEMBL8926076

[CH2]C(C)C(=O)OCC(C)Cc1ccccc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.49
RAB9A P51151 1/20 0.49
ALDH1A1 P00352 1/20 0.44
THRB P10828 1/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44
HSD17B10 Q99714 1/20 0.44
CTSL P07711 1/20 0.43
LMNA P02545 1/20 0.43
EGFR P00533 1/20 0.43
CYP1A2 P05177 1/20 0.43
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
ATM Q13315 1/20 0.42
TAAR1 Q96RJ0 1/20 0.42
CYP3A4 P08684 1/20 0.42
MAPK1 P28482 1/20 0.42
TSHR P16473 1/20 0.41
SRR Q9GZT4 1/20 0.41
MAPT P10636 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24073103 0.86 NPC1 (0.51) NPC1RAB9AALDH1A1THRBCYP2C9
SCHEMBL7260000 0.85 CYP3A4 (0.50) NPC1RAB9AALDH1A1THRBCYP2C9
SCHEMBL5622799 0.84 NPC1 (0.53) NPC1RAB9AALDH1A1THRBCYP2C9
SCHEMBL10886546 0.83 ALDH1A1 (0.56) NPC1RAB9AALDH1A1THRBCYP2C9
SCHEMBL15247513 0.83 ALDH1A1 (0.56) NPC1RAB9AALDH1A1THRBCYP2C9
SCHEMBL16137501 0.83 ALDH1A1 (0.56) NPC1RAB9AALDH1A1THRBCYP2C9
SCHEMBL24073169 0.82 NPC1 (0.47) NPC1RAB9AALDH1A1THRBCYP2C9
SCHEMBL7292741 0.81 NPC1 (0.50) NPC1RAB9AALDH1A1THRBCYP2C9
SCHEMBL7292748 0.81 PKM (0.54) NPC1RAB9AALDH1A1THRBCYP2C9
SCHEMBL22911682 0.81 PKM (0.54) NPC1RAB9AALDH1A1THRBCYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5639770-A SUPEROXIDE INHIBITOR OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1997-06-17 US disclosed
EP-0600092-A1 THIAZOLE DERIVATIVE OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1994-06-08 EP disclosed