Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | VCP | P55072 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | HPRT1 | P00492 | 5/20 | 0.46 |
| ▸ | TK1 | P04183 | 2/20 | 0.46 |
| ▸ | PNP | P00491 | 5/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | EDNRA | P25101 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | HBB | P68871 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8742951 | 0.83 | BLM (0.48) | BLMMEN1ALDH1A1LMNACYP3A4 | |
| SCHEMBL8742956 | 0.83 | BLM (0.48) | BLMMEN1ALDH1A1LMNACYP3A4 | |
| SCHEMBL8743090 | 0.83 | BLM (0.48) | BLMMEN1ALDH1A1LMNACYP3A4 | |
| SCHEMBL8927158 | 0.82 | BLM (0.47) | BLMMEN1ALDH1A1LMNACYP3A4 | |
| SCHEMBL8743564 | 0.79 | BLM (0.57) | BLMMEN1ALDH1A1LMNACYP3A4 | |
| SCHEMBL27293671 | 0.77 | AHCY (0.53) | ALDH1A1 | |
| SCHEMBL8927516 | 0.77 | AHCY (0.53) | ALDH1A1 | |
| SCHEMBL27923065 | 0.77 | XDH (0.55) | BLMMEN1ALDH1A1LMNACYP3A4 | |
| SCHEMBL7765224 | 0.75 | TK1 (0.57) | BLMMEN1ALDH1A1LMNACYP3A4 | |
| SCHEMBL8927607 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5644043-A | ANTITUMOR, ANTICANCER, TREATMENT OF HERPES | ELI LILLY AND COMPANY (US) | 1997-07-01 | — | — | US | disclosed |
| US-5574021-A | LEUKEMIA | ELI LILLY AND COMPANY (US) | 1996-11-12 | — | — | US | disclosed |
| EP-0329348-B1 | 2',3'-Dideoxy-2',2'-difluoronucleosides | LILLY CO ELI (US) | 1995-07-12 | — | — | EP | disclosed |
| EP-0329348-A2 | 2',3'-Dideoxy-2',2'-difluoronucleosides | ELI LILLY AND COMPANY (US) | 1989-08-23 | — | — | EP | disclosed |