Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8926985 | 0.83 | PLA2G2A (0.60) | PLA2G2A | |
| SCHEMBL8505410 | 0.73 | PLA2G2A (0.54) | L3MBTL1MAPK1NPSR1LMNAPLA2G2A | |
| SCHEMBL8924682 | 0.72 | PLA2G2A (0.61) | PLA2G2A | |
| SCHEMBL8924465 | 0.72 | PLA2G2A (0.60) | PLA2G2A | |
| SCHEMBL8926032 | 0.72 | PLA2G2A (0.61) | PLA2G2A | |
| SCHEMBL8926749 | 0.71 | PLA2G2A (0.49) | L3MBTL1MAPK1NPSR1MEN1HTT | |
| SCHEMBL8927003 | 0.70 | PLA2G2A (0.62) | PLA2G2A | |
| SCHEMBL8926080 | 0.69 | PLA2G2A (0.64) | PLA2G2A | |
| SCHEMBL8503352 | 0.69 | PLA2G2A (0.52) | L3MBTL1MAPK1LMNAPLA2G2AADORA1 | |
| SCHEMBL8924471 | 0.69 | PLA2G2A (0.46) | LMNAPLA2G2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5684034-A | INHIBITORS OF HUMAN NON-PANCREATIC SECRETORY PHOSPHOLIPASE A2, TREATMENT OF SEPTIC SHOCK, TRAUMA, RESPIRATORY DISORDERS, RHEUMATIC ARTHRITIS, INHIBITORS OF ARACHIDONIC ACID RELEASE | ELI LILLY AND COMPANY (US) | 1997-11-04 | — | — | US | disclosed |