Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 9/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8926990 | 0.84 | PLA2G2A (0.70) | PLA2G2A | |
| SCHEMBL8926742 | 0.78 | PLA2G2A (0.48) | PLA2G2AL3MBTL1LMNAALDH1A1MEN1 | |
| SCHEMBL8926048 | 0.75 | PLA2G2A (0.71) | PLA2G2A | |
| SCHEMBL8927009 | 0.74 | PLA2G2A (0.74) | PLA2G2A | |
| SCHEMBL8924693 | 0.74 | PLA2G2A (0.70) | PLA2G2A | |
| SCHEMBL8926577 | 0.73 | PLA2G2A (0.69) | PLA2G2A | |
| SCHEMBL8924312 | 0.73 | PLA2G2A (0.72) | PLA2G2AMTNR1AMTNR1B | |
| SCHEMBL8926059 | 0.72 | PLA2G2A (0.71) | PLA2G2AMTNR1AMTNR1B | |
| SCHEMBL8926090 | 0.72 | PLA2G2A (0.72) | PLA2G2A | |
| SCHEMBL8926735 | 0.71 | L3MBTL1 (0.43) | PLA2G2AL3MBTL1LMNAALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5684034-A | INHIBITORS OF HUMAN NON-PANCREATIC SECRETORY PHOSPHOLIPASE A2, TREATMENT OF SEPTIC SHOCK, TRAUMA, RESPIRATORY DISORDERS, RHEUMATIC ARTHRITIS, INHIBITORS OF ARACHIDONIC ACID RELEASE | ELI LILLY AND COMPANY (US) | 1997-11-04 | — | — | US | disclosed |