Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | IKBKB | O14920 | 3/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1225673 | 0.85 | PTGS2 (0.44) | MEN1KMT2AGAAPTGS2NPC1 | |
| SCHEMBL27934992 | 0.84 | PTGS2 (0.43) | MEN1KMT2AGAAPTGS2NPC1 | |
| SCHEMBL8597229 | 0.83 | PTGS2 (0.49) | MEN1KMT2APTGS2ALDH1A1KDM4E | |
| SCHEMBL10971135 | 0.82 | PTGS2 (0.42) | MEN1KMT2AGAAPTGS2NPC1 | |
| SCHEMBL2468990 | 0.82 | PTGS2 (0.45) | MEN1KMT2AGAAPTGS2ALDH1A1 | |
| SCHEMBL15428634 | 0.81 | NPC1 (0.48) | PTGS2NPC1RAB9AIKBKBPARP1 | |
| SCHEMBL14948995 | 0.81 | ALDH1A1 (0.46) | MEN1KMT2AGAAPTGS2NPC1 | |
| SCHEMBL12877520 | 0.78 | PTGS2 (0.42) | MEN1KMT2AGAAPTGS2KDM4E | |
| SCHEMBL2929763 | 0.78 | PTGS1 (0.54) | MEN1KMT2AGAAPTGS2ALDH1A1 | |
| SCHEMBL2471388 | 0.78 | PTPN1 (0.46) | MEN1KMT2AGAAPTGS2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4407815-A | AMINO ACID DERIVATIVE ANTIBIOTICS | BEECHAM GROUP LIMITED (GB) | 1983-10-04 | — | — | US | claimed |
| US-20190054068-A1 | Indole Amide Derivatives and Related Compounds for Use in the Treatment of Neurodegenerative Diseases | REMYND (BE) | 2019-02-21 | — | — | US | disclosed |
| US-8618138-B2 | Indole amide derivatives and related compounds for use in the treatment of neurodegenerative diseases | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2013-12-31 | — | — | US | disclosed |
| US-20120083475-A1 | INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2012-04-05 | — | — | US | disclosed |
| US-6414013-B1 | KINASE INHIBITORS; ANTICANCER AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2002-07-02 | — | — | US | disclosed |
| EP-0073100-B1 | BETA-LACTAM COMPOUNDS, THEIR PREPARATION AND THEIR USE | BEECHAM GROUP PLC (GB) | 1985-10-02 | — | — | EP | disclosed |
| EP-0067518-B1 | MODIFIED BETA-LACTAM COMPOUNDS | BEECHAM GROUP PLC (GB) | 1985-08-21 | — | — | EP | disclosed |
| US-4517124-A | REACTION OF A MERCAPTAN TO FORM ANTIVIOTIC | BEECHAM GROUP LIMITED (GB) | 1985-05-14 | — | — | US | disclosed |
| EP-0046363-B1 | PROCESS FOR THE PREPARATION OF 2-THIO PENEM DERIVATIVES AND INTERMEDIATES THEREFOR | BEECHAM GROUP PLC (GB) | 1984-11-14 | — | — | EP | disclosed |
| EP-0034443-B1 | BETA-LACTAM ANTIBACTERIAL COMPOUNDS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1984-09-26 | — | — | EP | disclosed |
| US-4463010-A | 1-Aza-[3.2.0]-bicycloheptane-2-carboxylic acid, ester or salt thereof | BEECHAM GROUP P.L.C. (GB) | 1984-07-31 | — | — | US | disclosed |
| US-4407815-A | AMINO ACID DERIVATIVE ANTIBIOTICS | BEECHAM GROUP LIMITED (GB) | 1983-10-04 | — | — | US | disclosed |
| US-4387051-A | β-Lactam antibiotics, their preparation and their use in pharmaceutical compositions | BEECHAM GROUP LIMITED (GB) | 1983-06-07 | — | — | US | disclosed |
| EP-0073100-A1 | Beta-lactam compounds, their preparation and their use | BEECHAM GROUP PLC (GB) | 1983-03-02 | — | — | EP | disclosed |
| EP-0067518-A1 | Modified beta-lactam compounds | BEECHAM GROUP PLC (GB) | 1982-12-22 | — | — | EP | disclosed |
| EP-0046363-A1 | Process for the preparation of 2-thio penem derivatives and intermediates therefor | BEECHAM GROUP PLC (GB) | 1982-02-24 | — | — | EP | disclosed |
| EP-0034443-A2 | Beta-lactam antibacterial compounds, their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1981-08-26 | — | — | EP | disclosed |
| EP-0028497-A1 | Beta-lactam antibiotics, their preparation and their use in pharmaceutical compositions | BEECHAM GROUP PLC (GB) | 1981-05-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120083475-A1 | INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | SNCA, MAPT, NLN | MEN1 3335/4885KMT2A 2251/4885GAA 346/4885 |
| US-20190054068-A1 | Indole Amide Derivatives and Related Compounds for Use in the Treatment of Neurodegenerative Diseases | SNCA, MAPT, NLN | MEN1 3335/4885KMT2A 2251/4885GAA 346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.