Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | AHR | P35869 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 3/20 | 0.46 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14099575 | 0.85 | MAPT (0.49) | MEN1MAPTKMT2AKDM4EALDH1A1 | |
| SCHEMBL11371014 | 0.74 | MAPT (0.61) | MEN1MAPTKMT2AKDM4EALDH1A1 | |
| SCHEMBL10497609 | 0.74 | MAPT (0.55) | ALOX5MEN1MAPTKMT2AKDM4E | |
| SCHEMBL14524716 | 0.72 | MAOB (0.76) | MAOB | |
| SCHEMBL5581839 | 0.72 | MAOB (0.76) | MAOB | |
| SCHEMBL5581835 | 0.72 | MAOB (0.76) | MAOB | |
| SCHEMBL260978 | 0.72 | KDM4E (0.50) | MEN1MAPTKMT2AKDM4EALDH1A1 | |
| SCHEMBL1429142 | 0.72 | ALDH1A1 (0.55) | MEN1MAPTKMT2AKDM4EALDH1A1 | |
| SCHEMBL4324078 | 0.72 | ALDH1A1 (0.55) | MEN1MAPTKMT2AKDM4EALDH1A1 | |
| SCHEMBL9150115 | 0.71 | MAOB (0.85) | NPC1RAB9AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5643896-A | TREATMENT OF MENOPAUSE SYMPTOMS, OSTEOPOROSIS, CARDIOVASCULAR DISORDERS OR ESTROGEN DEPENDENT CANCER | ELI LILLY AND COMPANY (US) | 1997-07-01 | — | — | US | disclosed |
| WO-1996026935-A1 | 2-BENZYL-3-ARYLBENZOTHIOPHENES | ELI LILLY AND COMPANY (US) | 1996-09-06 | — | — | WO | disclosed |
| EP-0729955-A1 | 2-Benzyl-3-Arylbenzothiophenes useful for the treatment of post-menopausal syndrome | ELI LILLY AND COMPANY (US) | 1996-09-04 | — | — | EP | disclosed |
| US-5552401-A | CARDIOVASCULAR DISORDERS, OSTEOPOROSIS AND ANTITUMOR AGENTS | ELI LILLY AND COMPANY (US) | 1996-09-03 | — | — | US | disclosed |