Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8927579 | 0.86 | KMT2A (0.40) | POLBKMT2APPARAPPARGPPARD | |
| SCHEMBL8810087 | 0.75 | KMT2A (0.39) | POLBKMT2ALMNAMAPTL3MBTL1 | |
| SCHEMBL9457262 | 0.73 | POLB (0.50) | POLBKMT2ALMNAMAPTL3MBTL1 | |
| Water SCHEMBL9457015 | 0.73 | POLB (0.49) | POLBKMT2ALMNAMAPTL3MBTL1 | |
| SCHEMBL8927401 | 0.73 | POLB (0.45) | POLBKMT2ALMNAMAPTTP53 | |
| SCHEMBL9275747 | 0.65 | DRD4 (0.49) | MAPTKDM4EALDH1A1DRD4MAPK1 | |
| SCHEMBL9271163 | 0.64 | HTR1A (0.43) | KMT2ALMNAMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL9272499 | 0.64 | POLB (0.38) | POLBDRD4RAB9A | |
| SCHEMBL8811666 | 0.64 | KMT2A (0.54) | POLBKMT2AMAPTL3MBTL1TP53 | |
| SCHEMBL9274889 | 0.64 | MAPT (0.43) | KMT2ALMNAMAPTL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607932-A | Heterocyclic derivatives of azolones | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-03-04 | — | — | US | disclosed |