Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | CHRNE | Q04844 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD4 | P21917 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8927579 | 0.90 | KMT2A (0.40) | KMT2APOLBRAB9ABCHECHRNE | |
| SCHEMBL9456969 | 0.76 | POLB (0.52) | KMT2APOLBRAB9ABCHECHRNE | |
| SCHEMBL8927049 | 0.75 | POLB (0.47) | KMT2APOLBRAB9ABCHECHRNE | |
| SCHEMBL9457409 | 0.72 | KMT2A (0.66) | KMT2APOLBRAB9ABCHECHRNE | |
| SCHEMBL8811666 | 0.71 | KMT2A (0.54) | KMT2APOLBRAB9ABCHECHRNE | |
| SCHEMBL10277001 | 0.68 | MEN1 (0.47) | KMT2APOLBRAB9AMEN1NPC1 | |
| SCHEMBL8931123 | 0.60 | DRD2 (0.50) | POLBLMNADRD2DRD4HTR1A | |
| SCHEMBL8931195 | 0.60 | DRD2 (0.50) | POLBRAB9ASMN1; SMN2LMNADRD2 | |
| SCHEMBL6353150 | 0.60 | HTR1A (0.64) | KMT2ARAB9ALMNADRD2DRD4 | |
| SCHEMBL8927401 | 0.60 | POLB (0.45) | KMT2APOLBBCHECHRNELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0770073-A1 | ANTI-HELICOBACTER HETEROCYCLIC DERIVATIVES OF AZOLONES | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-05-02 | — | — | EP | disclosed |
| US-5607932-A | Heterocyclic derivatives of azolones | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-03-04 | — | — | US | disclosed |
| WO-1996001821-A1 | ANTI-HELICOBACTER HETEROCYCLIC DERIVATIVES OF AZOLONES | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-01-25 | — | — | WO | disclosed |