Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.42 |
| ▸ | ME2 | P23368 | 1/20 | 0.41 |
| ▸ | ME1 | P48163 | 1/20 | 0.41 |
| ▸ | ME3 | Q16798 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | CHRNE | Q04844 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL9457015 | 0.99 | POLB (0.49) | POLBKMT2AMAPTTP53LMNA | |
| SCHEMBL8927401 | 0.90 | POLB (0.45) | POLBKMT2AMAPTTP53LMNA | |
| SCHEMBL8931753 | 0.84 | L3MBTL1 (0.41) | POLBMAPTADRB2ADRB1ADRB3 | |
| SCHEMBL9456969 | 0.81 | POLB (0.52) | POLBKMT2AMAPTTP53LMNA | |
| SCHEMBL11070469 | 0.79 | BRD9 (0.54) | POLBKMT2AMAPTLMNABRD9 | |
| SCHEMBL11069372 | 0.76 | MAPT (0.49) | POLBKMT2AMAPTLMNABRD9 | |
| SCHEMBL9462045 | 0.75 | MAPT (0.45) | POLBKMT2AMAPTTP53LMNA | |
| SCHEMBL8927581 | 0.73 | POLB (0.36) | POLBKMT2AMAPTTP53LMNA | |
| SCHEMBL11085992 | 0.73 | SMN1; SMN2 (0.49) | POLBKMT2AMAPTLMNABRD9 | |
| SCHEMBL9457409 | 0.72 | KMT2A (0.66) | POLBKMT2AMAPTTP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5254553-A | 4-[4- [4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-5-methyl-3H-1,2,4-triazol-3-one derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-10-19 | — | — | US | disclosed |
| EP-0532091-A1 | 4-(4-(4-(4-hydroxyphenyl)-1-piperazinyl)-phenyl)-5-methyl-3H-1,2,4-triazol-3-one derivatives as 5-lipoxygenase inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-17 | — | — | EP | disclosed |