SCHEMBL8927627

SCHEMBL8927627

[CH2]c1ccccc1NC(=O)N(C)C

nearest known ligand 0.55

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.49
HTT P42858 1/20 0.46
TSHR P16473 1/20 0.43
MASP2 O00187 1/20 0.41
ABCC1 P33527 1/20 0.41
KDM4E B2RXH2 1/20 0.41
KMT2A Q03164 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7089269 0.86 ALDH1A1 (0.56) ALDH1A1HTTTSHRMASP2ABCC1
SCHEMBL30761772 0.86 ALDH1A1 (0.56) ALDH1A1HTTTSHRMASP2ABCC1
SCHEMBL4048833 0.78 GAA (0.53) ALDH1A1HTTTSHRKDM4EKMT2A
SCHEMBL5814278 0.78 NPC1 (0.64) ALDH1A1HTTKDM4EKMT2A
SCHEMBL30782571 0.78 GAA (0.53) ALDH1A1HTTTSHRKDM4EKMT2A
SCHEMBL840655 0.78 ALDH1A1 (0.61) ALDH1A1HTTTSHRKDM4EKMT2A
SCHEMBL3837851 0.78 MAPT (0.52) ALDH1A1HTTTSHR
SCHEMBL23169175 0.77 HTT (0.64) ALDH1A1HTTKMT2A
SCHEMBL7202775 0.77 TP53 (0.59) ALDH1A1HTTTSHR
SCHEMBL560265 0.77 CYP1A2 (0.55) ALDH1A1TSHRKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5614498-A OLIGOPEPTIDES, BRONCHDILATORS BANYU PHARMACEUTICAL CO., LTD. (JP) 1997-03-25 US disclosed
US-5496928-A Endothelin antagonistic substance BANYU PHARMACEUTICAL CO., LTD. (JP) 1996-03-05 US disclosed
EP-0555537-A2 Endothelin antagonistic substance BANYU PHARMACEUTICAL CO., LTD. (JP) 1993-08-18 EP disclosed