Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9508261 | 0.78 | MEN1 (0.44) | MEN1KMT2AALDH1A1RAB9ANPC1 | |
| SCHEMBL15444335 | 0.77 | MAPT (0.59) | MEN1KMT2AMAPTPOLBL3MBTL1 | |
| SCHEMBL20299314 | 0.76 | SNCA (0.46) | CA2MEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL631327 | 0.73 | SNCA (0.62) | CA2MEN1KMT2AMAPTPOLB | |
| SCHEMBL29407421 | 0.73 | SNCA (0.62) | CA2MEN1KMT2AMAPTPOLB | |
| SCHEMBL31720743 | 0.73 | SNCA (0.62) | CA2MEN1KMT2AMAPTPOLB | |
| SCHEMBL28208846 | 0.71 | PRMT1 (0.50) | MEN1KMT2AMAPTPOLBALDH1A1 | |
| SCHEMBL22187521 | 0.71 | CA2 (0.71) | CA2MEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL7036230 | 0.69 | PRMT1 (0.51) | CA2MEN1KMT2AMAPTCA12 | |
| SCHEMBL11710601 | 0.69 | MEN1 (0.74) | MEN1KMT2AMAPTPOLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0458901-B1 | INHIBITING TRANSFORMATION OF CELLS HAVING ELEVATED PURINE METABOLIC ENZYME ACTIVITY | MASSACHUSETTS INST TECHNOLOGY (US) | 1997-12-17 | — | — | EP | disclosed |
| US-5324731-A | Method of inhibiting transformation of cells in which purine metabolic enzyme activity is elevated | AMIRA, INC. (US) | 1994-06-28 | — | — | US | disclosed |