Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 6/20 | 0.78 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.78 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8928104 | 0.87 | MTNR1A (1.00) | MTNR1AMTNR1B | |
| SCHEMBL8472235 | 0.85 | ALDH1A1 (0.63) | MTNR1AMTNR1BALDH1A1POLBKMT2A | |
| SCHEMBL13725463 | 0.85 | MTNR1A (0.79) | MTNR1AMTNR1BHDAC1HDAC6ALDH1A1 | |
| SCHEMBL29991337 | 0.83 | MTNR1A (0.77) | MTNR1AMTNR1BHDAC1HDAC6KMT2A | |
| SCHEMBL8928132 | 0.83 | MTNR1A (0.92) | MTNR1AMTNR1BHDAC1HDAC6KMT2A | |
| SCHEMBL28850813 | 0.83 | MTNR1A (0.77) | MTNR1AMTNR1BHDAC1HDAC6KMT2A | |
| SCHEMBL17143946 | 0.83 | ALDH1A1 (0.74) | MTNR1AMTNR1BALDH1A1POLB | |
| SCHEMBL8928116 | 0.83 | MTNR1A (0.71) | MTNR1AMTNR1BHDAC1HDAC6ALDH1A1 | |
| SCHEMBL8928085 | 0.82 | MTNR1A (0.75) | MTNR1AMTNR1BHDAC1HDAC6KMT2A | |
| SCHEMBL8928118 | 0.82 | MTNR1A (1.00) | MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5541228-A | Melatonergic agents | BRISTOL-MYERS SQUIBB CO. (US) | 1996-07-30 | — | — | US | claimed |
| EP-0706994-A1 | Melatonergic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-04-17 | — | — | EP | claimed |
| US-5661185-A | AN ALKOXYPHENYL-ALKYLUREA COMPOUND TREATING SLEEP DISORDER | BRISTOL-MYERS SQUIBB CO. (US) | 1997-08-26 | — | — | US | disclosed |
| US-5541228-A | Melatonergic agents | BRISTOL-MYERS SQUIBB CO. (US) | 1996-07-30 | — | — | US | disclosed |
| EP-0706994-A1 | Melatonergic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-04-17 | — | — | EP | disclosed |