SCHEMBL8928133

SCHEMBL8928133

COc1cccc(CCCCNC(=O)C(C)C)c1

nearest known ligand 0.70

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 4/20 0.67
MTNR1B P49286 3/20 0.67
KMT2A Q03164 3/20 0.59
CYP2D6 P10635 1/20 0.59
CYP2C9 P11712 1/20 0.59
CYP2C19 P33261 1/20 0.59
HDAC1 Q13547 1/20 0.57
HDAC6 Q9UBN7 1/20 0.57
ALDH1A1 P00352 1/20 0.57
MAPT P10636 1/20 0.57
NQO2 P16083 1/20 0.56
MEN1 O00255 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8928123 0.96 MTNR1A (0.73) MTNR1AMTNR1BKMT2ACYP2D6CYP2C9
SCHEMBL8928132 0.85 MTNR1A (0.92) MTNR1AMTNR1BKMT2AHDAC1HDAC6
SCHEMBL8928103 0.83 MTNR1A (0.69) MTNR1AMTNR1BKMT2AHDAC1HDAC6
SCHEMBL8928088 0.83 MTNR1A (0.92) MTNR1AMTNR1BHDAC1HDAC6
SCHEMBL15831224 0.82 ALDH1A1 (0.65) ALDH1A1
SCHEMBL31036087 0.82 MTNR1A (0.90) MTNR1AMTNR1BHDAC1HDAC6
SCHEMBL8928131 0.82 MTNR1A (0.68) MTNR1AMTNR1BKMT2AHDAC1HDAC6
SCHEMBL13725463 0.81 MTNR1A (0.79) MTNR1AMTNR1BKMT2AHDAC1HDAC6
SCHEMBL8928104 0.81 MTNR1A (1.00) MTNR1AMTNR1B
SCHEMBL8928067 0.81 MTNR1A (0.74) MTNR1AMTNR1BHDAC1HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5541228-A Melatonergic agents BRISTOL-MYERS SQUIBB CO. (US) 1996-07-30 US claimed
EP-0706994-A1 Melatonergic agents BRISTOL-MYERS SQUIBB COMPANY (US) 1996-04-17 EP claimed
US-5661185-A AN ALKOXYPHENYL-ALKYLUREA COMPOUND TREATING SLEEP DISORDER BRISTOL-MYERS SQUIBB CO. (US) 1997-08-26 US disclosed
US-5541228-A Melatonergic agents BRISTOL-MYERS SQUIBB CO. (US) 1996-07-30 US disclosed
EP-0706994-A1 Melatonergic agents BRISTOL-MYERS SQUIBB COMPANY (US) 1996-04-17 EP disclosed