SCHEMBL8930486

SCHEMBL8930486

C=CCN1C[C@H](C)N(c2c(Cc3cccc(C(=O)N(C)c4cccc(F)c4)c3)cccc2OC)C[C@H]1C

nearest known ligand 0.55

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
OPRD1 P41143 3/20 0.55
OPRM1 P35372 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4576511 0.90 OPRD1 (0.59) OPRD1
SCHEMBL8930490 0.87 OPRD1 (0.40) OPRD1OPRM1
SCHEMBL17909955 0.81 OPRD1 (0.61) OPRD1
SCHEMBL4591531 0.80 OPRD1 (0.45) OPRD1
SCHEMBL5146343 0.79 OPRD1 (0.45) OPRD1
SCHEMBL4599120 0.78 OPRD1 (0.44) OPRD1
SCHEMBL9212660 0.75 KDM4E (0.41) OPRD1
SCHEMBL8078564 0.74 OPRD1 (0.81) OPRD1OPRM1
SCHEMBL6915923 0.73 OPRD1 (0.43) OPRD1OPRM1
SCHEMBL15061338 0.72 OPRD1 (0.88) OPRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5552404-A COMPOUNDS FOR NEUROTRANSMITTERS FOR ANIMALS DELTA PHARMACEUTICALS, INC. (US) 1996-09-03 US claimed
US-5681830-A DIARYLMETHYL PIPERAZINE COMPOUNDS HAVING UTILITY IN MEDICAL THERAPY AS RECEPTOR-BINDING SPECIES DELTA PHARMACEUTICALS, INC. (US) 1997-10-28 US disclosed
US-5574159-A DIARYLMETHYL PIPERAZINES, RECEPTOR BINDING DELTA PHARMACEUTICALS, INC. (US) 1996-11-12 US disclosed