Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | DGAT1 | O75907 | 5/20 | 0.54 |
| ▸ | DEGS1 | O15121 | 2/20 | 0.38 |
| ▸ | ME2 | P23368 | 1/20 | 0.37 |
| ▸ | ME1 | P48163 | 1/20 | 0.37 |
| ▸ | ME3 | Q16798 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9287329 | 0.92 | MAPT (0.64) | MAPTGAAKDM4EALDH1A1LMNA | |
| SCHEMBL9284187 | 0.91 | MAPT (0.55) | MAPTGAAKDM4EALDH1A1LMNA | |
| SCHEMBL8931691 | 0.90 | DGAT1 (0.53) | MAPTGAAKDM4EALDH1A1LMNA | |
| SCHEMBL8931741 | 0.90 | DGAT1 (0.52) | MAPTGAAKDM4EALDH1A1LMNA | |
| SCHEMBL8931762 | 0.87 | DGAT1 (0.55) | MAPTGAAKDM4EALDH1A1LMNA | |
| Propanol SCHEMBL8926281 | 0.86 | DGAT1 (0.46) | MAPTGAAKDM4EALDH1A1LMNA | |
| SCHEMBL8926249 | 0.84 | DGAT1 (0.51) | MAPTGAAKDM4EALDH1A1LMNA | |
| SCHEMBL8931713 | 0.84 | DGAT1 (0.64) | MAPTGAAKDM4EALDH1A1LMNA | |
| SCHEMBL8931715 | 0.83 | DGAT1 (0.55) | MAPTGAAKDM4EALDH1A1LMNA | |
| SCHEMBL8927419 | 0.83 | DGAT1 (0.47) | MAPTGAAKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5650411-A | BACTERICIDES FOR HELICOBACTER DISEASES AND BACTERIA RESISTANCE | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-07-22 | — | — | US | disclosed |
| EP-0684821-A1 | SUBSTITUTED AZOLONE DERIVATIVES FOR TREATING DISEASES CAUSED BY HELICOBACTER | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-12-06 | — | — | EP | disclosed |
| WO-1994018978-A1 | SUBSTITUTED AZOLONE DERIVATIVES FOR TREATING DISEASES CAUSED BY HELICOBACTER | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-09-01 | — | — | WO | disclosed |