Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 4/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | SLC6A7 | Q99884 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8814915 | 0.93 | DGAT1 (0.51) | DGAT1CYP3A4MAPTGAAKDM4E | |
| SCHEMBL8927419 | 0.90 | DGAT1 (0.47) | DGAT1CYP3A4MAPTGAAKDM4E | |
| SCHEMBL8815089 | 0.90 | DGAT1 (0.51) | DGAT1CYP3A4MAPTGAAKDM4E | |
| SCHEMBL8927569 | 0.90 | DGAT1 (0.53) | DGAT1CYP3A4MAPTGAAKDM4E | |
| Propanol SCHEMBL8926281 | 0.90 | DGAT1 (0.46) | DGAT1CYP3A4MAPTGAAKDM4E | |
| SCHEMBL8931761 | 0.89 | DGAT1 (0.54) | DGAT1CYP3A4MAPTGAAKDM4E | |
| SCHEMBL8814492 | 0.89 | DGAT1 (0.48) | DGAT1CYP3A4SLC6A7MAPTGAA | |
| SCHEMBL8926713 | 0.89 | DGAT1 (0.44) | DGAT1CYP3A4MAPTGAAKDM4E | |
| SCHEMBL8931691 | 0.89 | DGAT1 (0.53) | DGAT1CYP3A4MAPTGAAKDM4E | |
| SCHEMBL8931121 | 0.89 | DGAT1 (0.53) | DGAT1MAPTGAAKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607932-A | Heterocyclic derivatives of azolones | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-03-04 | — | — | US | disclosed |