Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 5/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | GFER | P55789 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | ME2 | P23368 | 6/20 | 0.59 |
| ▸ | ME1 | P48163 | 6/20 | 0.59 |
| ▸ | ME3 | Q16798 | 6/20 | 0.59 |
| ▸ | CA12 | O43570 | 1/20 | 0.59 |
| ▸ | CA1 | P00915 | 1/20 | 0.59 |
| ▸ | CA2 | P00918 | 1/20 | 0.59 |
| ▸ | CA9 | Q16790 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.52 |
| ▸ | HTR3B | O95264 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7041242 | 0.90 | MAPT (0.68) | DRD4GAAALDH1A1LMNAGFER | |
| SCHEMBL7258870 | 0.87 | LMNA (0.64) | DRD4GAAALDH1A1LMNAKMT2A | |
| Phenol SCHEMBL28272307 | 0.85 | MAPT (0.56) | DRD4GAAALDH1A1LMNAGFER | |
| SCHEMBL385012 | 0.84 | — | — | |
| SCHEMBL576814 | 0.84 | LMNA (0.67) | DRD4GAAALDH1A1LMNAKMT2A | |
| SCHEMBL164538 | 0.84 | LMNA (0.67) | DRD4GAAALDH1A1LMNAKMT2A | |
| SCHEMBL16924853 | 0.84 | LMNA (0.67) | DRD4GAAALDH1A1LMNAKMT2A | |
| SCHEMBL576454 | 0.84 | LMNA (0.67) | DRD4GAAALDH1A1LMNAKMT2A | |
| SCHEMBL7106841 | 0.83 | KDM4E (0.61) | DRD4GAAALDH1A1LMNAGFER | |
| Phenol SCHEMBL28279448 | 0.82 | ALDH1A1 (0.53) | DRD4GAAALDH1A1LMNAGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5650411-A | BACTERICIDES FOR HELICOBACTER DISEASES AND BACTERIA RESISTANCE | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-07-22 | — | — | US | disclosed |
| CN-1118138-A | Substituted azolone derivatives for treating diseases caused by helicobacter | JANSSEN PHARMACEUTICA NV (BE) | 1996-03-06 | — | — | CN | disclosed |
| EP-0684821-A1 | SUBSTITUTED AZOLONE DERIVATIVES FOR TREATING DISEASES CAUSED BY HELICOBACTER | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-12-06 | — | — | EP | disclosed |
| WO-1994018978-A1 | SUBSTITUTED AZOLONE DERIVATIVES FOR TREATING DISEASES CAUSED BY HELICOBACTER | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-09-01 | — | — | WO | disclosed |
| EP-0331232-B1 | 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols | JANSSEN PHARMACEUTICA NV (BE) | 1994-05-18 | — | — | EP | disclosed |
| US-5254553-A | 4-[4- [4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-5-methyl-3H-1,2,4-triazol-3-one derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-10-19 | — | — | US | disclosed |
| CN-1021223-C | PROCESS FOR 5-LIPOXYGENSE INHIBITING 4-(4-PHENYL-1-PIP-ERAZING 1) PHENOLS | JANSSEN PHARMACEUTICA NV (BE) | 1993-06-16 | — | — | CN | disclosed |
| EP-0532091-A1 | 4-(4-(4-(4-hydroxyphenyl)-1-piperazinyl)-phenyl)-5-methyl-3H-1,2,4-triazol-3-one derivatives as 5-lipoxygenase inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-17 | — | — | EP | disclosed |
| EP-0331232-A3 | 5-LIPOXYGENASE INHIBITING 4-(4-PHENYL-1-PIPERAZINYL)PHENOLS | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-04-24 | — | — | EP | disclosed |
| EP-0331232-A3 | 5-LIPOXYGENASE INHIBITING 4-(4-PHENYL-1-PIPERAZINYL)PHENOLS | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-04-24 | — | — | EP | disclosed |
| US-4931444-A | FOR LEUKOTRIENE-MEDIATED DISEASES AND DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-06-05 | — | — | US | disclosed |
| US-4931444-A | FOR LEUKOTRIENE-MEDIATED DISEASES AND DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-06-05 | — | — | US | disclosed |
| CN-1036569-A | Preparation can suppress the method for 4-(4-phenyl-peiperazinyl) phenyl derivatives of 5-lipoxygenase | JANSSEN PHARMACEUTICA NV (BE) | 1989-10-25 | — | — | CN | disclosed |
| EP-0331232-A2 | 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-09-06 | — | — | EP | disclosed |
| EP-0331232-A2 | 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-09-06 | — | — | EP | disclosed |