Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.31 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.31 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.31 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27336722 | 0.77 | IDO1 (0.39) | ACHE | |
| SCHEMBL14359572 | 0.73 | SHBG (0.38) | ACHENR1H2NR1H3 | |
| SCHEMBL17586853 | 0.72 | MAPK1 (0.43) | ACHEMAPK1MAP2K4MAPKAPK2MAPKAPK3 | |
| SCHEMBL1920935 | 0.72 | ACHE (0.39) | ACHENR1H2NR1H3 | |
| SCHEMBL30302974 | 0.72 | MAPK1 (0.43) | ACHEMAPK1MAP2K4MAPKAPK2MAPKAPK3 | |
| SCHEMBL806289 | 0.72 | MAPK1 (0.43) | ACHEMAPK1MAP2K4MAPKAPK2MAPKAPK3 | |
| SCHEMBL4316095 | 0.72 | IDO1 (0.54) | RIPK1 | |
| SCHEMBL93024 | 0.72 | IDO1 (0.54) | RIPK1 | |
| SCHEMBL29664506 | 0.70 | TYR (0.50) | — | |
| SCHEMBL2898583 | 0.70 | TYR (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1043575-C | Silylated acetylcholinesterase inhibitors | MERRELL DOW PHARMA (US) | 1999-06-09 | — | — | CN | disclosed |
| EP-0684951-B1 | SILYLATED ACETYLCHOLINESTERASE INHIBITORS | MERRELL PHARMA INC (US) | 1997-05-07 | — | — | EP | disclosed |
| US-5523442-A | TREATING ALZHEIMER'S, DEMENTIA | MERRELL PHARMACEUTICALS INC. (US) | 1996-06-04 | — | — | US | disclosed |
| CN-1117733-A | Silylated acetylcholinesterase inhibitors | MERRELL DOW PHARMA (US) | 1996-02-28 | — | — | CN | disclosed |
| EP-0684951-A1 | SILYLATED ACETYLCHOLINESTERASE INHIBITORS. | MERRELL DOW PHARMA (US) | 1995-12-06 | — | — | EP | disclosed |
| WO-1994019356-A1 | SILYLATED ACETYLCHOLINESTERASE INHIBITORS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-09-01 | — | — | WO | disclosed |
| EP-0611769-A1 | Silylated acetylcholinesterase inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-08-24 | — | — | EP | disclosed |