Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | CES1 | P23141 | 2/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ALB | P02768 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27318018 | 0.84 | ACHE (0.46) | ACHEPLA2G2DHTTCES1MAPK1 | |
| SCHEMBL28452833 | 0.80 | ALB (0.46) | CES1CES2BCHEALOX15KDM4E | |
| SCHEMBL2194781 | 0.76 | CES1 (0.63) | ACHEPLA2G2DHTTCES1CES2 | |
| SCHEMBL26599005 | 0.73 | KAT6A (0.44) | PLA2G2DHTTCES1CES2BCHE | |
| SCHEMBL2782446 | 0.73 | PLA2G2D (0.41) | ACHEPLA2G2DHTTCES1CES2 | |
| SCHEMBL8587854 | 0.72 | NOTUM (0.43) | ACHEPLA2G2DHTTCES1CES2 | |
| SCHEMBL8932128 | 0.72 | ACHE (0.42) | ACHECES1CES2HDAC6HDAC4 | |
| SCHEMBL2781854 | 0.70 | ALDH1A1 (0.41) | PLA2G2DHTTCES1HDAC6HDAC4 | |
| SCHEMBL31283629 | 0.70 | ACHE (0.37) | ACHEHTTCES1MAPK1 | |
| SCHEMBL2637233 | 0.70 | ACHE (0.37) | ACHEHTTCES1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0684951-B1 | SILYLATED ACETYLCHOLINESTERASE INHIBITORS | MERRELL PHARMA INC (US) | 1997-05-07 | — | — | EP | claimed |