Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.56 |
| ▸ | CES1 | P23141 | 3/20 | 0.37 |
| ▸ | CES2 | O00748 | 2/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8932122 | 0.81 | KDM4E (0.43) | ACHECES1CES2 | |
| SCHEMBL20309068 | 0.78 | CSNK2A1 (0.41) | ACHECES1CES2HTTALDH1A1 | |
| SCHEMBL15264662 | 0.76 | ACHE (0.37) | ACHEHDAC6ALDH1A1 | |
| SCHEMBL121698 | 0.76 | TMPRSS4 (0.44) | CES1CES2ALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL13698761 | 0.75 | ACHE (0.53) | ACHECES1CES2HTTMAPK1 | |
| SCHEMBL8932130 | 0.75 | ACHE (0.44) | ACHE | |
| SCHEMBL24166639 | 0.74 | MAPT (0.41) | CES1CES2HTTMAPK1PLA2G2D | |
| SCHEMBL30531094 | 0.74 | TRPV1 (0.40) | CES1CES2MAPK1PLA2G2D | |
| SCHEMBL18295855 | 0.74 | CES1 (0.39) | ACHECES1CES2HTTMAPK1 | |
| SCHEMBL2966997 | 0.74 | DGAT1 (0.47) | CES1CES2ALDH1A1GLASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0684951-B1 | SILYLATED ACETYLCHOLINESTERASE INHIBITORS | MERRELL PHARMA INC (US) | 1997-05-07 | — | — | EP | claimed |