Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ASPH | Q12797 | 1/20 | 0.43 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | ALB | P02768 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8932112 | 0.81 | ACHE (0.56) | ACHECES2CES1 | |
| SCHEMBL12188075 | 0.77 | KDM4E (0.57) | KDM4EACHECYP3A4HPGDKEAP1 | |
| SCHEMBL28514216 | 0.77 | CES2 (0.39) | KDM4EASPHKDM8ACHECES2 | |
| SCHEMBL28515999 | 0.74 | ALDH1A1 (0.55) | KDM4ECYP3A4HPGD | |
| SCHEMBL9730784 | 0.74 | RXRB (0.47) | KDM4EACHEHPGD | |
| SCHEMBL87104 | 0.74 | CSNK2A1 (0.61) | KDM4ECES2CES1 | |
| SCHEMBL31011348 | 0.74 | CSNK2A1 (0.61) | KDM4ECES2CES1 | |
| SCHEMBL5833638 | 0.73 | ACE2 (0.44) | KDM4EACHEHPGDLMNA | |
| SCHEMBL115334 | 0.73 | CES2 (0.71) | KDM4EASPHKDM8CYP3A4CES2 | |
| SCHEMBL5597538 | 0.72 | CSNK2A1 (0.59) | KDM4ECES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1043575-C | Silylated acetylcholinesterase inhibitors | MERRELL DOW PHARMA (US) | 1999-06-09 | — | — | CN | disclosed |
| EP-0684951-B1 | SILYLATED ACETYLCHOLINESTERASE INHIBITORS | MERRELL PHARMA INC (US) | 1997-05-07 | — | — | EP | disclosed |
| US-5523442-A | TREATING ALZHEIMER'S, DEMENTIA | MERRELL PHARMACEUTICALS INC. (US) | 1996-06-04 | — | — | US | disclosed |
| EP-0684951-A1 | SILYLATED ACETYLCHOLINESTERASE INHIBITORS. | MERRELL DOW PHARMA (US) | 1995-12-06 | — | — | EP | disclosed |
| WO-1994019356-A1 | SILYLATED ACETYLCHOLINESTERASE INHIBITORS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-09-01 | — | — | WO | disclosed |
| EP-0611769-A1 | Silylated acetylcholinesterase inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-08-24 | — | — | EP | disclosed |