Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.60 |
| ▸ | PGK1 | P00558 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | GALR2 | O43603 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | FBP1 | P09467 | 1/20 | 0.42 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12626671 | 0.86 | EGFR (0.60) | EGFRPGK1LMNAABCG2FBP1 | |
| SCHEMBL8932207 | 0.84 | EGFR (0.50) | EGFRLMNAGALR2POLBABCG2 | |
| SCHEMBL15929508 | 0.83 | EGFR (0.49) | EGFRLMNAGALR2POLBABCG2 | |
| SCHEMBL30275314 | 0.82 | EGFR (0.54) | EGFRPGK1LMNAVCAM1PDGFRB | |
| SCHEMBL1469486 | 0.82 | EGFR (0.54) | EGFRPGK1LMNAVCAM1PDGFRB | |
| SCHEMBL7466349 | 0.81 | EGFR (0.67) | EGFRABCG2 | |
| SCHEMBL8932198 | 0.81 | EGFR (0.64) | EGFRLMNAGALR2POLBABCG2 | |
| SCHEMBL7802761 | 0.79 | EGFR (0.72) | EGFRABCG2FBP1 | |
| SCHEMBL7465009 | 0.78 | HTT (0.57) | EGFRPGK1LMNA | |
| SCHEMBL7461665 | 0.78 | USP10 (0.59) | EGFRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188274-B2 | Process for preparing aminocrotonylamino-substituted quinazoline derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-05-29 | — | — | US | disclosed |
| US-8188274-B2 | Process for preparing aminocrotonylamino-substituted quinazoline derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-05-29 | — | — | US | disclosed |
| US-8067593-B2 | Process for preparing aminocrotonylamino-substituted quinazoline derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-11-29 | — | — | US | disclosed |
| US-20110207929-A1 | Process for preparing aminocrotonylamino-substituted quinazoline derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-08-25 | — | — | US | disclosed |
| US-20110207929-A1 | Process for preparing aminocrotonylamino-substituted quinazoline derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-08-25 | — | — | US | disclosed |
| US-20110207932-A1 | Process for preparing aminocrotonylamino-substituted quinazoline derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-08-25 | — | — | US | disclosed |
| US-7960546-B2 | Process for preparing aminocrotonylamino-substituted quinazoline derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-06-14 | — | — | US | disclosed |
| US-20090306378-A1 | PROCESS FOR PREPARING AMINOCROTONYLAMINO-SUBSTITUTED QUINAZOLINE DERIVATIVES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110207932-A1 | Process for preparing aminocrotonylamino-substituted quinazoline derivatives | EGFR, CNKSR1, ERBB2 | EGFR 1/4885PGK1 1202/4885LMNA 4013/4885 |
| US-20090306378-A1 | PROCESS FOR PREPARING AMINOCROTONYLAMINO-SUBSTITUTED QUINAZOLINE DERIVATIVES | EGFR, CNKSR1, ERBB2 | EGFR 1/4885PGK1 1049/4885LMNA 3779/4885 |
| US-20110207929-A1 | Process for preparing aminocrotonylamino-substituted quinazoline derivatives | EGFR, CNKSR1, ERBB2 | EGFR 1/4885PGK1 1202/4885LMNA 4013/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.