Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 10/20 | 0.56 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 8/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL10836227 | 0.98 | DRD2 (0.55) | DRD2CHRNB2CHRNA4HTR1AESR1 | |
| Bromide SCHEMBL7851578 | 0.98 | DRD2 (0.55) | DRD2CHRNB2CHRNA4HTR1AESR1 | |
| SCHEMBL10505280 | 0.85 | ADRA2A (0.47) | DRD2ESR1ESR2 | |
| Bromide SCHEMBL10506337 | 0.84 | ADRA2A (0.46) | DRD2ESR1ESR2 | |
| Bromide SCHEMBL10835837 | 0.84 | ADRA2A (0.46) | DRD2ESR1ESR2 | |
| Bromide SCHEMBL10835832 | 0.84 | ADRA2A (0.46) | DRD2ESR1ESR2 | |
| Bromide SCHEMBL10836781 | 0.80 | STS (0.43) | DRD2ESR1ESR2 | |
| SCHEMBL7853405 | 0.77 | HSD11B1 (0.59) | DRD2HTR1A | |
| SCHEMBL8136238 | 0.77 | HSD11B1 (0.59) | DRD2HTR1A | |
| SCHEMBL7853400 | 0.77 | HSD11B1 (0.59) | DRD2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996022991-A1 | BICYCLIC SUBSTITUTED HEXAHYDROBENZ[E]ISOINDOLE ALPHA-1- ADRENERGIC ANTAGONISTS | ABBOTT LABORATORIES (US) | 1996-08-01 | — | — | WO | disclosed |
| WO-1996022992-A1 | TRICYCLIC SUBSTITUTED HEXAHYDROBENZ[E]ISOINDOLE ALPHA-1 ADRENERGIC ANTAGONISTS | ABBOTT LABORATORIES (US) | 1996-08-01 | — | — | WO | disclosed |