Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 4/20 | 0.50 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.50 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.50 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.50 |
| ▸ | PTAFR | P25105 | 10/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.45 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11825305 | 0.87 | GABRA1 (0.51) | GABRA1GABRA5GABRA2GABRB2PTAFR | |
| SCHEMBL11830483 | 0.85 | GABRA1 (0.58) | GABRA1GABRA5GABRA2GABRB2GABRA3 | |
| SCHEMBL11826943 | 0.85 | PTAFR (0.47) | GABRA1GABRA5GABRA2GABRB2PTAFR | |
| SCHEMBL11830831 | 0.83 | GABRA1 (0.49) | GABRA1GABRA5GABRA2GABRB2PTAFR | |
| SCHEMBL32673434 | 0.83 | OPRK1 (0.57) | GABRA1GABRA5GABRA2PTAFRGABRA3 | |
| SCHEMBL11729005 | 0.83 | OPRK1 (0.57) | GABRA1GABRA5GABRA2PTAFRGABRA3 | |
| SCHEMBL11827953 | 0.81 | GABRA1 (0.53) | GABRA1GABRA5GABRA2GABRB2PTAFR | |
| SCHEMBL8933572 | 0.80 | CYP3A4 (0.47) | GABRA1GABRA5GABRA2GABRB2PTAFR | |
| SCHEMBL11835141 | 0.80 | PTAFR (0.45) | GABRA1GABRA5GABRA2GABRB2PTAFR | |
| SCHEMBL11826404 | 0.79 | GABRA3 (0.63) | GABRA1GABRA5GABRA2GABRB2PTAFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996023790-A1 | ACETYLIMIDAZOBENZODIAZEPINES | F. HOFFMANN-LA ROCHE AG (CH) | 1996-08-08 | — | — | WO | disclosed |
| US-3933794-A | CENTRAL NERVOUS SYSTEM DEPRESSANTS | THE UPJOHN COMPANY (US) | 1976-01-20 | — | — | US | disclosed |