SCHEMBL8934185

SCHEMBL8934185

O=C1CSC(Cl)c2ccccc21

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.42
S100A4 P26447 3/20 0.40
SMN1; SMN2 Q16637 2/20 0.38
ACHE P22303 1/20 0.34
IDO1 P14902 2/20 0.33
HPGD P15428 2/20 0.33
CDC25B P30305 2/20 0.33
POLB P06746 1/20 0.33
MAOA P21397 1/20 0.33
MAOB P27338 1/20 0.33
AKT1 P31749 1/20 0.33
SNCA P37840 1/20 0.33
MAP2K1 Q02750 1/20 0.33
PIN1 Q13526 1/20 0.33
EHMT2 Q96KQ7 1/20 0.33
NSD1 Q96L73 1/20 0.33
EHMT1 Q9H9B1 1/20 0.33
ADORA3 P0DMS8 1/20 0.32
AR P10275 1/20 0.32
HSD11B1 P28845 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7514071 0.73 ALDH1A1 (0.40) ALDH1A1SMN1; SMN2ACHEHPGDPOLB
SCHEMBL9379556 0.73 ALDH1A1 (0.43) ALDH1A1SMN1; SMN2HPGDPOLBMEN1
SCHEMBL5139023 0.70 ALDH1A1 (0.38) ALDH1A1SMN1; SMN2ACHEHPGDPOLB
SCHEMBL28148310 0.69 S100A4 (0.64) ALDH1A1S100A4ACHECDC25BMAOB
SCHEMBL8933984 0.68 ALDH1A1 (0.36) ALDH1A1HPGDPOLBADORA3AR
SCHEMBL9384978 0.68 ALDH1A1 (0.39) ALDH1A1SMN1; SMN2HPGDPOLBL3MBTL1
SCHEMBL20395206 0.65 S100A4 (0.44) ALDH1A1S100A4ACHEIDO1CDC25B
SCHEMBL12405330 0.64 S100A4 (0.47) ALDH1A1S100A4ACHECDC25BMAOB
SCHEMBL86285 0.64 EDNRB (0.41) ALDH1A1S100A4SMN1; SMN2IDO1HPGD
SCHEMBL19302757 0.63 AR (0.46) ALDH1A1S100A4MAOBADORA3AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1996009304-A1 BENZOPYRANOPYRAZOLYL DERIVATIVES FOR THE TREATMENT OF INFLAMMATION G.D. SEARLE & CO. (US) 1996-03-28 WO disclosed